摘要
目的探究贝那普利对肾小球肾炎患者肾功能和肾小球硬化的改善效果。方法选取2018年1月至2019年7月收治的100例肾小球肾炎患者,采用单双号法随机分组,即单号为对照组(n=50,来氟米特)、双号为试验组(n=50,贝那普利+来氟米特)。比较两组的治疗效果。结果试验组的治疗总有效率为94.00%,高于对照组的76.00%(P<0.05)。治疗后,两组的24 h尿蛋白、BUN、Scr、UAER水平均降低,eGFR、Ccr水平均升高,且试验组明显优于对照组(P<0.05)。治疗后,两组的肾小球硬化评分均降低,且试验组明显低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论贝那普利治疗肾小球肾炎患者的效果显著,可改善肾功能,降低其肾小球硬化程度。
Objective To investigate the improvement effect of benazepril on renal function and glomerulosclerosis in patients with glomerulonephritis.Methods A total of 100 patients with glomerulonephritis admitted from January 2018 to July 2019 were selected and randomly grouped by the odd and even number method,the single number was control group(n=50,leflunomide)and the double number was experimental group(n=50,benazepril+leflunomide).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the experimental group was 94.00%,which was higher than 76.00%in the control group(P<0.05).After treatment,24 h urinary protein,BUN,Scr,UAER levels of the two groups decreased,eGFR and Ccr levels increased,and those in the experimental group were significantly better than the control group(P<0.05).After treatment,the glomerulosclerosis scores of the two groups decreased,and that in the experimental group was significantly lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Benazepril in the treatment of patients with glomerulonephritis has a significant effect,which can improve renal function and reduce the degree of glomerulosclerosis.
作者
宋博峰
雷西彦
SONG Bofeng;LEI Xiyan(Qishan County Hospital,Baoji 722400;Ansai District People's Hospital,Yan'an 717400,China)
出处
《临床医学研究与实践》
2020年第29期51-52,60,共3页
Clinical Research and Practice
关键词
贝那普利
肾小球肾炎
肾功能
肾小球硬化
benazepril
glomerulonephritis
renal function
glomerulosclerosis
