摘要
目的探讨长春西汀对血管性痴呆患者临床疗效及炎症因子水平的影响。方法将60例血管性痴呆患者随机分为观察组及对照组,每组30例。观察组在基础治疗方案上给予长春西汀注射液,对照组在基础治疗方案上给予艾地苯醌片,均连续治疗2周。于治疗2周后进行疗效评定,比较治疗前及治疗2周后两组患者血清白细胞介素(IL)-6、C反应蛋白(CRP)、肿瘤坏死因子(TNF)-α水平,以及简易精神状态检查(MMSE)评分和Lawton日常生活能力量表(ADL)评分。结果观察组治疗总有效率为96.7%(29/30),高于对照组的70.0%(P<0.05)。治疗后两组患者血清IL-6、CRP、TNF-α水平及Lawton ADL评分均较治疗前下降,MMSE评分较治疗前提高,且观察组患者血清IL-6、CRP、TNF-α水平及Lawton ADL评分均低于对照组,MMSE评分高于对照组(均P<0.05)。结论在基础治疗方案上联合长春西汀治疗血管性痴呆,可降低患者血清炎性因子水平,提高认知功能及日常生活能力。
Objective To investigate the effects of vinpocetine on clinical efficacy and levels of inflammatory factors in patients with vascular dementia.Methods Sixty patients with vascular dementia were randomly divided into observation group and control group,with 30 cases in each group.The observation group was given Vinpocetine Injection based on the regimen of basic treatment,while the control group was given Idebenone Tablets based on the regimen of basic treatment,both groups were treated for two consecutive weeks.Efficacy assessment was performed two weeks after treatment,serum interleukin(IL)-6,C-reactive protein(CRP)and tumor necrosis factor(TNF)-αlevels,as well as the Mini-Mental State Examination(MMSE)scores and Lawton Activity of Daily Living(ADL)scores were compared between the two groups before treatment and two weeks after treatment.Results The total therapeutic effective rate in the observation group was higher than that in the control group(96.7%[29/30]vs.70.0%,P<0.05).After treatment,serum IL-6,CRP and TNF-αlevels and Lawton ADL scores were decreased while MMSE scores were increased in both groups as compared with those before treatment,and the observation group exhibited lower serum IL-6,CRP and TNF-αlevels,lower Lawton ADL scores and higher MMSE scores than the control group(all P<0.05).Conclusion In combination with the regimen of basic treatment vinpocetine can reduce serum levels of inflammatory factors and improve cognitive function and Lawton ADL in the treatment of patients with vascular dementia.
作者
王刚
仲婷婷
蒋毅
陈玺龙
王小勤
王慧云
WANG Gang;ZHONG Ting-ting;JIANG Yi;CHEN Xi-long;WANG Xiao-qin;WANG Hui-yun(Department of Neurology,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)
出处
《广西医学》
CAS
2020年第17期2244-2247,共4页
Guangxi Medical Journal
