摘要
目的探讨反复呼吸道感染儿童的免疫状态以及维生素A/E缺乏情况。方法纳入100例反复呼吸道感染患儿(观察组)以及80例体检儿童(对照组)。检测并比较两组血清维生素A和维生素E、T淋巴细胞亚群及免疫球蛋白水平,并比较两组维生素A、E缺乏以及细胞免疫功能异常的发生率。结果观察组血清维生素A水平以及IgA、IgG、IgM、CD3^+T淋巴细胞水平均低于对照组(均P<0.05),维生素A缺乏、细胞免疫抑制、CD3^+T淋巴细胞下降的发生率均高于对照组(均P<0.05)。但两组血清维生素E水平、CD4^+和CD8^+T淋巴细胞水平、CD4^+/CD8^+比值比较,差异均无统计学意义(均P>0.05)。结论反复呼吸道感染儿童血清维生素A水平降低且机体免疫失衡,更易出现维生素A缺乏与免疫抑制。维生素A缺乏或可通过影响机体的免疫状态而导致反复呼吸道感染的发生。
Objective To explore the immune condition and occurrence of vitamin A/E deficiency in children with repeated respiratory tract infection.Methods One hundred children with repeated respiratory tract infection and 80 children receiving medical examination were enrolled as observation group and control group,respectively.Serum vitamin A and vitamin E,T lymphocyte subsets and immunoglobulins levels of the two groups were determined and compared;besides,the incidence rates of vitamin A/E deficiency and cellular immunologic dysfunction were compared between the two groups.Results By compared with the control group,the observation group yielded lower serum vitamin A level,declined levels of IgA,IgG,IgM and CD3^+T lymphocyte(all P<0.05),as well as higher incidence rates of vitamin A deficiency,cellular immunity suppression and CD3^+T lymphocyte reduction(all P<0.05).However,there were no statistically significant differences in serum vitamin E level,CD4^+or CD8^+T lymphocyte level,or CD4^+/CD8^+ratio between the two groups(all P>0.05).Conclusion Children with repeated respiratory tract infection suffer from decreased serum vitamin A level and body immune condition imbalance,and are prone to develop vitamin A deficiency and immunosuppression.Vitamin A deficiency results in repeated respiratory tract infection probably by affecting body immune condition.
作者
陈洁琳
覃敏
杨晓祥
谭杰
莫荣浩
庞夏玲
冯燕华
黄丽莲
李英乔
江蕙芸
CHEN Jie-lin;QIN Min;YANG Xiao-xiang;TAN Jie;MO Rong-hao;PANG Xia-ling;FENG Yan-hua;HUANG Li-lian;LI Ying-qiao;JIANG Hui-yun(Department of Respiratory Medicine,the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region&Children Hospital of Guangxi Zhuang Autonomous Region,Nanning 530002,China;Department of Child Health Care,the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region&Children Hospital of Guangxi Zhuang Autonomous Region,Nanning 530002,China)
出处
《广西医学》
CAS
2020年第17期2199-2201,2205,共4页
Guangxi Medical Journal
基金
国家卫生计生委医药卫生科技发展研究中心项目(W2016EWQT01)
广西医疗卫生适宜技术开发与推广应用项目(S2018017)。
关键词
反复呼吸道感染
儿童
维生素A
维生素E
免疫功能
Repeated respiratory tract infection
Children
Vitamin A
Vitamin E
Immune function
