摘要
目的 探讨新型冠状病毒肺炎患者的临床特点及药物治疗方案.方法 回顾性分析2020年2月2-28日华中科技大学附属同济医院中法新城院区收治的50例新型冠状病毒肺炎患者的临床资料,分析患者的临床特点、治疗方案、治疗前后实验室指标变化及治愈率.结果 50例新型冠状病毒肺炎患者临床症状主要包括咳嗽咳痰、呼吸困难、发热、腹泻、肌肉酸痛等.影像学均表现为胸片/胸部CT双肺间质性病变.所有患者均采取药物治疗以及氧疗支持,药物治疗方案包括激素+抗菌治疗、抗病毒+激素治疗、抗病毒+抗菌治疗、抗病毒+激素+抗菌治疗,其中应用抗病毒+激素+抗菌治疗方案占比最高,达72%.阿比多尔为最常用抗病毒药物,使用率高达98%;甲泼尼龙为最常用激素,使用率为80%;莫西沙星为最常用抗菌药物,使用率达72%.50例患者初诊时有3例患者白细胞计数升高、4例患者降低;60%患者中性粒细胞百分比升高,74%患者淋巴细胞降低.治疗后7d和14 d的白细胞计数和淋巴细胞均较治疗前升高(P<0.05);中性粒细胞百分比和PCT均较治疗前降低(P<0.05).结论 新型冠状病毒肺炎患者的双肺间质性病变检出率较高,且患者多伴随咳嗽咳痰、呼吸困难、发热、腹泻、肌肉酸痛等症状与体征.以阿比多尔为基础结合实际情况联合激素或抗菌药治疗可有效改善患者血清学指标,治愈率高,值得参考.
OBJECTIVE To explore the clinical characteristics of patients with Corona Virus Disease 2019(COVID-19)and the treatment options.METHODS The clinical data of 50 patients with COVID-19 who were treated in the Sino-French New City Campus of Tongji Hospital,Huazhong University of Science and Technology from Feb 2,2020 to Feb 28,2020 were retrospectively analyzed.The clinical characteristics and treatment options of the patients were analyzed,the clinical laboratory test indexes were observed before and after the treatment,and the cure rate was analyzed.RESULTS The major clinical symptoms of the 50 patients with COVID-19 included cough,expectoration,dyspnea,fever,diarrhea and muscle soreness.The imaging findings of all the patients were characterized by chest radiograph/chest CT interstitial lesions in both lungs.All of the patients were given drug therapy and oxygen therapy.The drug treatment options included hormone plus antibacterial therapy,antiviral plus hormonal therapy,antiviral plus antibacterial therapy,antiviral plus hormone plus antibacterial therapy;the proportion of the patients who were given antiviral plus hormone plus antibacterial therapy was the highest(72%).Arbidol was the most commonly used antiviral drug,with the utilization rate 98%;methylprednisolone was the most commonly used hormone,with the utilization rate 80%;moxifloxacin was the most commonly used antibiotic,with the utilization rate 72%.Among the 50 patients,3 patients had increased white blood cell(WBC)counts,and 4 patients had decreased WBC counts;60%of the patients had increased percentage of neutrophils,and 74%of the patients had decreased lymphocytes counts.The WBC counts and lymphocytes level were significantly higher after the treatment for 7 and 14 days than before the treatment(P<0.05);the percentage of neutrophils and PCT level were significantly lower after the treatment than before the treatment(P<0.05).CONCLUSION The detection rate of interstitial lung lesions is high among the patients with COVID-19,and most of the patients
作者
杜艺
武卫东
王晓成
杨晓静
弓清梅
乔爱春
郭亚辉
DU Yi;WU Wei-dong;WANG Xiao-cheng;YANG Xiao-jing;GONG Qing-mei;QIAO Ai-chun;GUO Ya-hui(Shanxi Bethune Hospital,Taiyuan,Shanxi 030032,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第17期2579-2582,共4页
Chinese Journal of Nosocomiology
基金
山西省卫生健康委新冠病毒科研专项基金资助项目(4)。
