摘要
目的对邯郸市1例流行性脑脊髓膜炎病例进行个案调查及实验结果分析。方法通过查阅病案和现场询问,对该病例进行流行病学个案调查,并采集标本进行脑膜炎奈瑟菌的分离培养、生化鉴定、血清分群、基因分型和药敏试验。结果根据现场流行病学调查结果、临床特征,结合实验室检查结果,确定为C群脑膜炎奈瑟菌引起的脑膜炎,基因分型结果为ST-4821。药敏试验提示对环丙沙星、阿奇霉素、头孢噻肟、氯霉素、头孢曲松、美罗培南敏感,对萘啶酸和磺胺类药耐药。结论ST-4821属于高致病性克隆群,提示需做好重点人群的预防接种,同时加强病原学的监测。
Objective To investigate one case of epidemic cerebrospinal meningitis and analyze the experimental results in Handan City.Methods Epidemiological case investigation was conducted by means of consulting medical records and on-site inquiry,and specimens were collected for Neisseria meningitides isolation and culture,biochemical identification,serum clustering,genotyping and drug susceptibility test.Results According to the results of field epidemiological investigation,clinical characteristics and laboratory examination,the case was identified as meningitis caused by Neisseria meningitides group C,and the genotyping result was ST-4821.Drug sensitivity test indicated that it was sensitive to ciprofloxacin(CIP),azithromycin(AZI),cefotaxime(CEF),chloromycetin(CHL),ceftriazone(CTR),meropenem(MEM),and resistant to nalidixic acid and sulfonamide(SMZ).Conclusion The genotype of this case is ST-4821 which belongs to the highly pathogenic clone group.It is suggested that we should do a good job of inoculation in the key population and strengthen the monitoring of pathogens.
作者
赵丽萍
黄亮
任文波
闫永飞
马艳霞
ZHAO Liping;HUANG Liang;REN Wenbo;YAN Yongfei;MA Yanxia(Handan Center for Disease Control and Prevention,Hebei 056000,China;不详)
出处
《医学动物防制》
2020年第9期915-916,共2页
Journal of Medical Pest Control
基金
邯郸市科技计划项目(1623208066-6)。
关键词
流行性脑脊髓膜炎
脑膜炎奈瑟菌
病原学监测
C群
流行病学
Epidemic cerebrospinal meningitis
Neisseria meningitides
Pathogen monitoring
Group C
Epidemiology
