摘要
目的探讨硫酸羟氯喹联合白芍总苷及艾拉莫德治疗原发性干燥综合征(pSS)的临床疗效。方法选取2018年2月~2019年2月成都市第六人民医院风湿免疫科门诊收治的76例pSS患者,随机数字表法分为对照组和观察组两组,每组各38例。对照组采用硫酸羟氯喹片200mg/次,2次/d,白芍总胶囊苷600mg/次,3次/d,口服治疗;观察组在对照组用药基础上联用艾拉莫德片口服25mg/次,2次/d,口服治疗。两组用药24周后对比治疗指标,以评价不同用药方案的临床疗效及安全性。结果与治疗前相比,两组治疗24周后血清免疫球蛋白、血沉、C反应蛋白、CD19+CD5+B淋巴细胞数量明显下降(P<0.05),且治疗后观察组各实验室指标下降优于对照组(P<0.05)。治疗后观察组眼Schirmer试验、唾液腺流率明显高于对照组,关节肿胀个数、VAS评分明显低于对照组(P<0.05)。治疗24周后观察组临床总显效率显著高于对照组,差异有统计学意义(P<0.05)。观察组恶心呕吐、腹泻等不良反应发生率稍高于对照组,但组间比较差异无统计学意义(P>0.05),且两组治疗期间均未见血尿常规、肝肾功能指标明显异常(P>0.05)。结论原发性干燥综合征在常规硫酸羟氯喹联合白芍总苷治疗基础上,合理联用我国自主研发的新药艾拉莫德,能进一步提高临床疗效,加快患者症状改善,且无严重不良反应,新用药方案具有较高的应用价值。
Objective The clinical efficacy of hydroxychloroquine sulfate combined with total glucosides of paeony and ilammod in the treatment of primary Sjogren's syndrome was analyzed.Methods The random number table of 76 pSS patients admitted to the outpatient department of rheumatology and immunology in the hospital from February 2018 to February 2019 was divided into two groups,each with 38 patients.The control group was treated with hydroxychloroquine sulfate 200 mg/time,2 times/d,the total glucosides of paeony capsules 600 mg/time,and 3 times/d orally.The observation group was combined with ilamold tablets 25 mg/Oral treatment twice,twice daily.The treatment indexes were compared after 24 weeks of treatment in the two groups to evaluate the clinical efficacy and safety of different treatment regimens.Results The number of serum immunoglobulin,erythrocyte sedimentation rate,C-reactive protein and CD19+CD5+B lymphocytes in the two groups decreased significantly after 24 weeks of treatment compared with that before treatment.After treatment,the laboratory indexes of the observation group decreased better than that of the control group.After treatment,the eye Schirmer test and salivary gland flow rate in the observation group were significantly higher than the control group,and the number of joint swelling and VAS score were significantly lower than the control group,with statistically significant differences(P<0.05).After 24 weeks of treatment,the total clinical efficiency of the observation group was 86.84%significantly higher than that of the control group(57.89%),with statistically significant difference(P<0.05).The incidence of adverse reactions such as nausea,vomiting and diarrhea in the observation group was 18.42%,slightly higher than that in the control group(13.16%),but the comparison between the groups was not statistically significant(P>0.05),and no significant abnormalities in routine hematuria and liver and kidney function indexes were observed in the two groups during treatment.Conclusion Primary Sjogren's
作者
谢欢
刘毅
王健
曾春雪
周雅璐
XIE Huan;LIU Yi;WANG Jian;ZENG Chunxue;ZHOU Yalu(Rheumatology and Immunology Department,Chengdu Sixth People’Hospital,Chengdu 610051,China;Rheumatology and Immunology Department,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《西部医学》
2020年第9期1358-1362,共5页
Medical Journal of West China
关键词
原发性干燥综合征
硫酸羟氯喹
白芍总苷
艾拉莫德
Primary sjogren's syndrome
Hydroxychloroquine sulfate
Total glycoside of radix paeoniae alba
Elamud
Curative effect
