摘要
本文介绍了长半衰期药物生物利用度研究的几种改进方法。长半衰期药物生物利用度试验中血样收集时间可不同于常规情况的3个以上半衰期，只须达到吸收完全即可，一般为24～36h。若吸收过程符合线性速率动力学，卷积回归法能够准确计算每个药动学参数，同时SIMA&KA和ESTF&KA计算程序又使求算大大简化，因而成为目前应用最为广泛也最为满意的方法。
The methods on the determination of the bioavailability for drugs with long elimination half-life were reviewed. All methods depended on the assumption of linear pharmacokinetics. Emphasis is laid on the regression methods of truncated areas-under-curves(AUC) to obtain estimate of bioavailability F, and the absorption rate constant Ka, without obeying the general rules of following blood or plasmal levels for at least three times the elimination half-life. It may take 24-36h to collect blood or plasma samples when the absorption was completed. Two PC-program , SIMF&KA and ESTE&KA , for the regression method of truncated areas can be used for the calculation of the AUC. So the method would be used widely to estimate the bioavailability of long elimination half-life.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2000年第5期397-399,共3页
The Chinese Journal of Clinical Pharmacology
