摘要
目的:探讨肝硬化食管静脉曲张破裂出血的相关影响因素。方法:选择蚌埠市第三人民医院诊断的肝硬化食管静脉曲张患者108例,按是否出血分为2组,未出血组50例,出血组58例。回顾性分析2组患者一般临床资料、实验室指标、影像学及内镜检查结果,采用单因素分析及多因素Logistic回归分析,筛选肝硬化食管静脉曲张破裂出血的相关影响因素。结果:单因素分析结果显示,2组患者血红蛋白、总胆红素、肌酐、凝血酶原时间、Child分级、食管静脉曲张大小、门脉高压性胃病、红色征、腹水、门静脉血栓情况比较差异有统计学意义(P<0.05);多因素Logistic分析结果显示,总胆红素、食管静脉曲张大小、红色征、Child分级是肝硬化食管静脉曲张破裂出血的独立危险因素;构建总胆红素、食管静脉曲张大小、红色征、Child分级对肝硬化食管静脉曲张破裂出血预测的ROC曲线,曲线下面积分别为0.655、0.640、0.753、0.632。结论:总胆红素、食管静脉曲张大小、红色征、Child分级是肝硬化食管静脉曲张破裂出血的独立影响因素,它们可预测出血的风险,且均具有较高的临床价值。
Objective:To explore the related risk factors of esophageal variceal bleeding in cirrhosis patients.Methods:108 cirrhosis patients with esophageal varices admitted to Bengbu Third People's Hospital were divided into two groups,with 50 patients in the unbleeding group and 58 patients in the bleeding group.General clinical data,laboratory data,imaging and endoscopic findings of the two groups were retrospectively analyzed.Univariate analysis and multivariate logistic regression analysis were used to explore the related risk factors of esophageal variceal bleeding in the cirrhosis patients.Results:Univariate analysis showed that there were significant differences in terms of hemoglobin,total bilirubin,creatinine,prothrombin time,Child classification,esophageal varices,portal hypertensive gastropathy,red sign,ascites and portal vein thrombosis between the two groups(P<0.05).Multivariate logistic regression analysis showed that total bilirubin,degree of esophageal varices,red sign and Child classification were independent risk factors for esophageal variceal bleeding in patients with liver cirrhosis.The ROC curves of total bilirubin,degree of esophageal varices,red sign and Child classification for predicting bleeding of esophageal varices in cirrhosis were constructed,and the areas under ROC curves were 0.655,0.640,0.753,0.632 respectively.Conclusion:Total bilirubin,degree of esophageal varices,red sign and Child classification are independent risk factors for esophageal variceal bleeding in patients with liver cirrhosis,which can predict the risk of esophageal variceal bleeding and have high predictive value.
作者
李晶
江泳
张旭
LI Jing;JIANG Yong;ZHANG Xu(Department of Gastroenterology, Bengbu Third People's Hospital, Anhui 233000, China)
出处
《淮海医药》
CAS
2020年第4期331-333,337,共4页
Journal of Huaihai Medicine
