摘要
目的探讨注射用丁二磺酸腺苷蛋氨酸对妊娠期肝内胆汁淤积症(ICP)患者肝功能、妊娠结局的影响。方法采用机械取样法将本院82例ICP患者分为观察组和对照组,各41例。对照组给予熊去氧胆酸,观察组在对照组的基础上给予注射用丁二磺酸腺苷蛋氨酸。比较两组的肝功能指标、血清因子水平、妊娠结局、围生儿情况及不良反应发生情况。结果用药后,两组患者AST、ALT及TBA水平均较用药前降低,且观察组低于对照组(P<0.05)。用药后,两组患者的VEGF、IL-17水平均低于用药前,TGF-β水平均高于用药前,且观察组优于对照组(P<0.05)。观察组患者的产后出血率、早产率及剖宫产率均低于对照组(P<0.05)。观察组的新生儿体质量高于对照组,新生儿窒息率及胎儿窘迫症发生率均低于对照组(P<0.05)。结论注射用丁二磺酸腺苷蛋氨酸治疗ICP,可改善患者的肝功能、妊娠结局及围产儿情况,且安全性高。
Objective To investigate the effect of ademetionine 1,4-butanedisulfonate for injection on liver function and pregnancy outcome in patients with intrahepatic cholestasis of pregnancy(ICP).Methods Eighty-two ICP patients enrolled in our hospital were divided into observation group and control group,with 41 cases in each group.The control group was given ursodeoxycholic acid,and the observation group was given ademetionine 1,4-butanedisulfonate for injection on the basis of the control group.The levels of liver function indexes and serum factors,pregnancy outcome,perinatal condition and adverse reactions were compared between the two groups.Results After medication,the levels of AST,ALT and TBA in both groups were lower than those before medication,and those of the observation group were lower than the control group(P<0.05).After medication,the levels of VEGF and IL-17 in both groups were lower than those before medication,the level of TGF-βwas higher than that before medication,and those of the observation group were better than the control group(P<0.05).The rates of postpartum hemorrhage,premature delivery and cesarean section in the observation group were lower than those in the control group(P<0.05).The neonatal body mass of the observation group was higher than that of the control group,and the incidences of neonatal asphyxia and fetal distress were lower than those of the control group(P<0.05).Conclusion Ademetionine 1,4-butanedisulfonate for injection in the treatment of ICP can improve the liver function,pregnancy outcome of patients and perinatal conditions,and has high safety.
作者
李菊
LI Ju(Xi'an No.3 Hospital,Xi'an 710018,China)
出处
《临床医学研究与实践》
2020年第27期88-90,共3页
Clinical Research and Practice
关键词
妊娠期肝内胆汁淤积症
注射用丁二磺酸腺苷蛋氨酸
妊娠结局
肝功能
intrahepatic cholestasis of pregnancy
ademetionine 1,4-butanedisulfonate for injection
pregnancy outcome
liver function
