摘要
阿替普酶(重组组织型纤溶酶原激活剂,rt-PA)静脉溶栓是目前国内外医治急性缺血性脑卒中(acute ischemic stroke,AIS)最有效的方法之一,其临床疗效已得到广泛验证,然而溶栓后继发出血转化(hemorrhagic transformation,HT)是其并发症之一,严重影响治疗效果及预后。溶栓后HT由多种危险因素引起,国内外很多学者和团队针对可能影响HT的危险因素进行了研究,并且建立了一系列预测模型预测静脉溶栓后HT的风险。本文就rt-PA静脉溶栓后继发HT的病变机制、危险因素及预测模型作一综述。
Intravenous thrombolysis with alteplase(recombinant tissue plasminogen activator,rt-PA)is one of the most effective methods to treat acute ischemic stroke(AIS).However,hemorrhagic transformation(HT)after thrombolysis is a serious complication,which affects the therapeutic effect and prognosis.Hemorrhagic transformation after thrombolysis is caused by a variety of risk factors.Many scholars and teams at home and abroad have studied the risk factors that may affect HT and established a series of prediction models to predict the risk of hemorrhagic transformation after intravenous thrombolysis.This article reviews the pathogenesis,risk factors and prediction models of secondary hemorrhagic transformation after rt-PA intravenous thrombolysis.
作者
罗晴蓉
李运飞
边林
张丽芳
LUO Qingrong;LI Yunfei;BIAN Lin;ZHANG Lifang(Changzhi Medical College,Changzhi 046000,China;Affiliated Changzhi People's Hospital of Changzhi Medical College,Changzhi 046000,China)
出处
《中国实用神经疾病杂志》
2020年第18期1652-1656,共5页
Chinese Journal of Practical Nervous Diseases
基金
山西省卫生计生委科研项目(编号:201602027)。
关键词
缺血性脑卒中
静脉溶栓
出血转化
危险因素
预测模型
Ischemic stroke
Intravenous thrombolysis
Hemorrhagic transformation
Risk factors
Prediction models
