摘要
目的:通过检测血清肿瘤标志物(SCC-Ag、CYFRA21-1、CEA、CA125、NSE)探讨联合检测对口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的临床诊断意义及诊断效能。方法:收集2015年1月至2018年1月就诊于新疆维吾尔自治区人民医院口腔颌面外科的OSCC患者60例,非OSCC恶性肿瘤患者60例,同期健康体检者60例作为正常组,均抽取空腹外周血2 ml,检测SCC-Ag、CYFRA21-1、CEA、CA125、NSE浓度。结果:OSCC患者的5种血清肿瘤标志物水平与非OSCC恶性肿瘤组、正常组比较差异具有统计学意义(P<0.05)。将CEA、CA125、SCC-Ag、CYFRA21-1、NSE联合检测后敏感性、特异性、准确性、阳性预测值均显著提高。结论:SCC-Ag、CYFRA21-1、CEA、CA125、NSE 5种肿瘤标志物在OSCC中联合检测可以显著提高诊断效能;5种肿瘤标志物的血清表达量在OSCC的临床诊断中具有一定的价值。
Objective:The clinical significance and diagnostic efficacy of combined detection for oral squamous cell carcinoma(OSCC) were investigated by detecting serum tumor markers(SCC-Ag,CYFRA21-1,CEA,CA125,NSE).Methods:Sixty patients with OSCC from 2015.1 to 2018.1,60 patients with non-OSCC malignant tumors,and 60 healthy subjects with normal physical examination were enrolled in the study.All patients were given 2 ml of fasting peripheral blood and tested for SCC-Ag,CYFRA21-1,CEA,CA125,NSE concentration.Results:The serum levels of tumor markers in OSCC patients were significantly different from those in non-OSCC malignant tumors and normal controls(P<0.05).The sensitivity,specificity,accuracy and positive predictive value of CEA,CA125,SCC-Ag,CYFRA21-1 and NSE were significantly improved.Conclusion:The combined detection of five tumor markers in OSCC can significantly improve the diagnostic efficiency.The serum expression of five tumor markers has certain value in the clinical diagnosis of OSCC.
作者
边勤疆
多力昆·吾甫尔
Bian Qinjiang;Duolikun·Wufuer(Department of Oral and Maxillofacial Surgery,Gansu Provincial Hospital,Gansu Lanzhou 730000,China;Department of Oral and Maxillofacial Surgery,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Urumqi 830000,China)
出处
《现代肿瘤医学》
CAS
2020年第19期3330-3333,共4页
Journal of Modern Oncology
关键词
肿瘤标志物
联合检测
口腔鳞状细胞癌
tumor markers
combine detection
oral squamous cell carcinoma
