摘要
目的研究圆齿野鸦椿Euscaphis konishii的化学成分。方法采用硅胶柱色谱,凝胶柱色谱、制备高效液相色谱等分离技术进行分离纯化,利用现代波谱学手段进行化合物结构鉴定。结果从圆齿野鸦椿95%乙醇提取物的醋酸乙酯部位中分离得到8个化合物,分别鉴定为4(R)-(4′-羟基苯甲酰)二氢呋喃-2(3H)-酮(1)、6-hydroxymellein(2)、euscapholide(3)、去氢催吐萝芙木醇(4)、没食子酸乙酯(5)、tetraketide(6)、对羟基苯甲酸(7)、烟碱酸(8)。结论化合物1为新化合物,命名为圆齿野鸦椿内酯;除化合物3和6外,其余均为首次从该属植物中分离得到。
Objective To study the chemical constituents of Euscaphis konishii. Methods The chemical constituents from 95% EtOH extract of the stems of E. konishii were isolated by repeated chromatograph with silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structure of the separated chemical components was identified by modern spectroscopy identification. Results Eight compounds were isolated from the ethyl acetate fraction of 95% EtOH extract of E. konishii, and identified as 4(R)-(4′-hydroxybenzoyl) dihydrofuran-2(3 H)-one(1), 6-hydroxymellein(2), euscapholide(3), dehydrovomifoliol(4), ethyl gallate(5), tetraketide(6), p-hydroxybenzoic acid(7) and nicotinic acid(8). Conclusion Except for compounds 3 and 6, they are all isolated for the first time in this genus, and all compounds are isolated for the first time in this plant. Among them, compound 1 is a new compound named konieuscaphide.
作者
陈景新
张丽媛
倪林
吴美婷
张琳婧
肖晓梅
李玉权
邹双全
CHEN Jing-xin;ZHANG Li-yuan;NI Lin;WU Mei-ting;ZHANG Lin-jing;XIAO Xiao-mei;LI Yu-quan;ZOU Shuang-quan(College of Plant Protection,Fujian Agriculture and Forestry University,Fuzhou 350002,China;Department of Food and Pharmaceutical Engineering,Shijiazhuang University of Applied Technology,Shijiazhuang 050081,China;Fujian Colleges and Universities Engineering Research Center of Conservation&Utilization of Natural Bioresources,Fujian Agriculture and Forestry University,Fuzhou 350002,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第18期4605-4609,共5页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(31700292)。
