摘要
目的探讨前列腺健康指数(PHI)在前列腺癌预测中的敏感性和特异性,为疑似前列腺癌患者是否行穿刺活检提供更有效的参考依据。方法收集2019年3月至2019年12月在延边大学附属医院就诊,筛查PSA异常且通过穿刺或前列腺电切获取病理结果的82例患者的术前血清检查和基本资料。采用受试者工作特征(ROC)曲线评价PHI诊断前列腺癌的价值。结果前列腺癌组PHI值高于非前列腺组[300(85.48~300)vs.37.54(24.16~47.76),Z=-6.851,P<0.001],差异有统计学意义(P<0.05);ROC曲线分析结果显示,PHI、tPSA诊断前列腺癌的曲线下面积(AUC)分别为0.942、0.797。tPSA灵敏度68.6%,特异度97.9%;PHI灵敏度85.7%,特异度93.6%。PHI对前列腺癌的诊断价值优于tPSA。结论在PSA轻度升高且没有明确病理结果时,PHI诊断前列腺癌的价值优于目前常用的tPSA,能更灵敏地预测前列腺癌,可作为前列腺癌的辅助诊断并在是否进行穿刺活检的选择上起到重要作用。
Objective To explore the sensitivity and specificity of prostate health index(PHI)in the prediction of prostate cancer,and to determine whether suspected prostate cancer patients need a puncture.Methods The preoperative serum tests and demographic data of 82 patients with abnormal prostate specific antigen(PSA)who underwent prostate puncture or resection during Mar.2019 and Dec.2019 in Yanbian University Hospital were collected.The value of PHI in the diagnosis of prostate cancer was evaluated with receiver operating characteristic(ROC)curve.Results The prostate cancer group had higher PHI than the non-prostate cancer group[300(85.48-300)vs.37.54(24.16-47.76),Z=-6.851,P<0.001].ROC curve showed that the area under the curve(AUC)of PHI and total PSA(tPSA)were 0.942 and 0.797,respectively.The sensitivity and specificity of tPSA were 68.6%and 97.9%,while the sensitivity and specificity of PHI were 85.7%and 93.6%,respectively.The PHI had better diagnostic value than tPSA.Conclusion When PSA is slightly elevated and there is no clear pathological result,the value of PHI in the diagnosis of prostate cancer is superior to that of t-PSA,which can more sensitively predict prostate cancer and determine whether a puncture is needed.
作者
蒋凯峰
雷震
朴敏虎
王伟
JIANG Kai-feng;LEI Zhen;PIAO Min-hu;WANG Wei(Department of Urology,Yanbian University Hospital,Yanji 133000;Department of Urology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)
出处
《现代泌尿外科杂志》
CAS
2020年第9期813-815,共3页
Journal of Modern Urology
