摘要
目的探讨慢性阻塞性肺疾病(慢阻肺)患者应用盐酸氨溴索治疗的效果及其对肺功能、免疫功能指标的影响。方法90例慢阻肺患者,采用随机数字表法分为干预组和对照组,各45例。干预组患者采用盐酸氨溴索治疗,对照组患者采用常规治疗。比较两组患者的治疗效果、临床症状消失时间、住院时间、动脉血氧分压(PaO2)、肺功能指标及免疫功能。结果干预组总有效率95.56%(43/45)显著高于对照组的77.78%(35/45),差异具有统计学意义(P<0.05)。干预组咳嗽消失时间、发热消失时间、肺部啰音消失时间、住院时间分别为(1.62±0.25)、(3.04±1.53)、(2.31±1.42)、(11.36±2.89)d,均短于对照组的(2.85±0.62)、(6.68±2.07)、(4.95±1.37)、(20.51±2.66)d,差异均有统计学意义(P<0.05)。干预组患者用力肺活量(FVC)、每分钟最大通气量(MVV)、第1秒用力呼气容积(FEV1)、PaO2分别为(4.61±0.82)L、(85.71±0.61)L、(3.27±0.65)L、(79.62±4.31)mm Hg(1 mm Hg=0.133 kPa),均显著优于对照组的(3.21±0.36)L、(72.56±0.75)L、(2.11±0.52)L、(75.85±5.16)mm Hg,差异均有统计学意义(P<0.05)。干预组患者免疫功能改善优良率93.33%(42/45)显著优于对照组的71.11%(32/45),差异具有统计学意义(P<0.05)。结论慢阻肺患者采用盐酸氨溴索治疗临床效果较显著,可有效改善患者肺功能指标、免疫功能指标,缩短患者临床症状消失时间,具有临床使用及推广价值。
Objective To discuss the effect of ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease and its influence on patients’pulmonary function and immune function indexes.Methods A total of 90 cases of chronic obstructive pulmonary disease patients were divided into intervention group and control group by random numerical table,with 45 cases in each group.The intervention group was treated with ambroxol hydrochloride,and the control group was treated with conventional therapy.The therapeutic effect,disappearance time of clinical symptoms,hospitalization time,arterial partial pressure of oxygen(PaO2),pulmonary function indexes and immune function of the two groups was compared.Results The total effective rate 95.56%(43/45)of the intervention group was significantly higher than that of the control group 77.78%(35/45),and the difference was statistically significant(P<0.05).The cough disappearance time,fever disappearance time,lung rales disappearance time and hospitalization time of the intervention group was(1.62±0.25),(3.04±1.53),(2.31±1.42)and(11.36±2.89)d,which was shorter than that of the control group(2.85±0.62),(6.68±2.07),(4.95±1.37)and(20.51±2.66)d,and the difference was statistically significant(P<0.05).The forced vital capacity(FVC),maximum voluntary ventilation(MVV),forced expiratory volume in the first second(FEV1)and PaO2 of the intervention group was(4.61±0.82)L,(85.71±0.61)L,(3.27±0.65)L and(79.62±4.31)mm Hg(1 mm Hg=0.133 kPa),which was significantly better than that of the control group(3.21±0.36)L,(72.56±0.75)L,(2.11±0.52)L/min and(75.85±5.16)mm Hg,and the difference was statistically significant(P<0.05).The excellent rate of immune function 93.33%(42/45)of the intervention group was significantly better than that of the control group 71.11%(32/45),and the difference was statistically significant(P<0.05).Conclusion Ambroxol hydrochloride shows remarkable clinical effect on patients with chronic obstructive pulmonary disease,which can improve the pulmonary fu
作者
曹玉贵
才蔚涛
马建国
CAO Yu-gui;CAI Wei-tao;MA Jian-guo(th Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China,Tangshan 063000,China)
出处
《中国实用医药》
2020年第26期99-102,共4页
China Practical Medicine
关键词
慢性阻塞性肺疾病
盐酸氨溴索
肺功能
免疫功能
临床症状
Chronic obstructive pulmonary disease
Ambroxol hydrochloride
Pulmonary function
Immune function
Clinical symptoms
