期刊文献+

缬沙坦联合螺内酯治疗顽固性心衰的疗效及对凝血功能、心功能的影响 被引量:5

The Effect of Valsartan Combined with Spironolactone in the Treatment of Refractory Heart Failure and its Influence on Coagulation and Cardiac Function
下载PDF
导出
摘要 目的探讨缬沙坦、螺内酯治疗顽固性心衰的疗效及对凝血功能、心功能的影响。方法以100例顽固性心衰患者为对象,分为观察组、对照组。对比两组临床疗效及凝血、心功能。结果观察组总有效率为90.00%(45/50),高于对照组(70.00%(35/50),P<0.05)。治疗后两组D二聚体(D-D)、血管性血友病因子(vWF)、心率(HR)、内皮素-1(ET-1)、一氧化氮(NO)水平降低,而活化部分凝血活酶时间(aPTT)、左室射血分数(LVEF)、每搏输出量(SV)水平升高,观察组降低/升高幅度高于对照组(P<0.05)。结论缬沙坦、螺内酯治疗顽固性心衰的效果较好,可改善患者凝血功能并提高患者心功能。
作者 魏晓红 蒙淑红 朝格 WEI Xiao-hong;MENG Shu-hong;CHAO Ge(Department of Cardiology,Bayannao City Hospital of Inner Mongolia Inner Mongolia Autonomous Region,Bayannao,015000,China)
出处 《血栓与止血学》 2020年第6期977-978,981,共3页 Chinese Journal of Thrombosis and Hemostasis
  • 相关文献

参考文献5

二级参考文献44

  • 1李春慧.洛汀新与缬沙坦对老年急性心肌梗死患者心室重塑及心功能的影响[J].中国老年学杂志,2015,35(1):82-84. 被引量:17
  • 2Matsumura K,Fujji K,Oniki H,et al.Role of aldosterene in left ventricular hypertrophy in hypertension[J].Am J Hypertens,2006,19(1):13-18. 被引量:1
  • 3Pitt B,Zannad F,Remme WJ,et al.The effect of spironolactone on morbidity and mortality in patients with severe heart failure.randomized aldactone evaluation study investigators[J].N Engl J Med,1999,341(10):709-717. 被引量:1
  • 4Struthers AD.The clinical implications of aldosterone escape in congestive heart failure[J].Eur J Heart Failure,2004,6(5):539-545. 被引量:1
  • 5Sato A,Saruta T.Aldosterone breakthrough during angiotensin converting enzyme inhibitor therapy[J].Am J Hypertens,2003,16(9):781-788. 被引量:1
  • 6Cohn JN,Anand IS,Latini R.Sustained Reducation of aldosterone in response to the angiotensin receptor blocker valsartan in patients with chronic heart failure:results from the valsartan heart failure trial[J].Circulation,2003,108(11):1306-1309. 被引量:1
  • 7Naruse M,Tanabe A,Sato A,et al.Aldosterone breakthrough during angiotensin Ⅱ receptor antagonist therapy in stroke-prone spontaneously hypertensive rats[J].Hypertension,2002,40(11):28-33. 被引量:1
  • 8Yu CM,Fang JWH,Zhang Q,et al.Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy[J].Circulation,2004,110(1):66-73. 被引量:1
  • 9Nagueh SF,Middleton KJ,Kopelen HA,et al.Doppler tissue imaging:a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures[J].J Am Coll Cardiol,1997,30(6):1527-1533. 被引量:1
  • 10Sanderson JE.New treatments for myocardial fibrosis[J].Cardiovasc Drugs Ther,2002,16(3):181-182. 被引量:1

共引文献31

同被引文献58

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部