摘要
目的观察喜炎平联合干扰素治疗手足口病伴有肝功能损伤患儿的临床疗效,为抗病毒治疗提供指导。方法选取2017年10月-2019年10月三亚市人民医院治疗的手足口病伴肝功能异常患儿124例,使用随机数表法将患者纳入观察组和对照组,每组62例。对照组:给予重组人干扰素α-2b,3 mIU/m^2皮下注射,1次/d,连用3 d。观察组:在对照组基础上,给予喜炎平注射液5~10 mg/kg静脉滴注,1次/d,连用3 d。测定并比较丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超氧化物歧化酶(SOD)、丙二醛(MDA)等临床指标。结果治疗前2组患者ALT、AST、SOD、MDA、TNF-α和IL-6表达水平差异无统计学意义。治疗3 d后观察组患者SOD表达水平显著高于对照组[(26.53±3.44)U/L vs(22.32±3.26)U/L;t=3.117,P<0.05],ALT、AST、MDA、TNF-α和IL-6表达水平均显著低于对照组[(70.46±12.24)U/L vs(92.58±14.47)U/L,(76.22±13.61)U/L vs(101.57±15.26)U/L,(20.12±2.46)mmol/L vs(25.17±3.05)mmol/L,(32.45±4.13)μmol/L vs(40.27±5.33)μmol/L,(24.14±3.34)μmol/L vs(31.24±5.02)μmol/L,P均<0.05]。观察组患者总有效率显著高于对照组[96.8%vs 82.3%,χ^2=2.914,P<0.05]。两组患者不良反应发生率差异无统计学意义(9.68%vs 11.29%,χ^2=0.322,P>0.05)。结论喜炎平联合干扰素治疗手足口病伴有肝功能损伤的患儿可提高临床疗效,并抑制患儿氧化应激炎症反应,发挥保护肝功能作用。
Objective To observe the effect of Xiyanping combined with interferon in the treatment of hand,foot and mouth disease with liver dysfunction.Methods From October 2017 to October 2019,124 cases with hand,foot and mouth disease were selected from People's Hospital of Sanya city and divided into control group(n=62)and observation group(n=62).The control group was given recombinant human interferonα-2 b at 3 mIU/m^2 subcutaneously once a day for 3 days.On the basis of the control group,observation group was given Xiyanping injection 5-10 mg/kg intravenous drip once a day for 3 days.ALT and AST were measured by immunoturbidimetry.TNF-αand IL-6 were measured by ELISA,SOD was detected by xanthine oxidase and MDA was detected by thiobarbituric acid analysis.Results There were no significant differences in ALT,AST,SOD,MDA,TNF-α,and IL-6 between the two groups before treatment(P all>0.05).After treatment for 3 days,SOD in observation group was significantly higher than that in the control group(26.53±3.44 vs 22.33±3.26;t=3.117,P<0.05),and AST,ALT,MDA,TNF-αand IL-6 in observation group were significantly lower than those in control group(70.46±12.24 vs 92.58±14.47;76.22±13.61 vs101.57±15.26;20.12±2.46 vs 25.17±3.05;32.45±4.13 vs 40.27±5.33;24.14±3.34 vs 31.24±5.02,all P<0.05).The clinic effective rate in observation group was higher than that in control group(96.8%vs82.3%;χ^2=2.914,P<0.05).There was no significant different adverse reactions between the two groups(9.68%vs 11.29%,χ^2=0.322,P>0.05).Conclusions Xiyanping combined with interferon can improve the clinical effect,inhibit oxidative stress and inflammatory reaction in children with hand,foot and mouth disease.
作者
陈宾
邢舒旺
陈东旭
陈丽
雷智贤
CHEN Bin;XING Shu-wang;CHEN Dong-xu;CHEN Li;LEI Zhi-xian(People’s Hospital of Sanya City,Sanya,Hainan 572000,China)
出处
《中国病毒病杂志》
CAS
2020年第4期275-278,共4页
Chinese Journal of Viral Diseases
基金
海南省自然科学基金(813245)。
关键词
喜炎平
干扰素
手足口病
肝损伤
炎症反应
氧化应激反应
Xiyanping
Interferon
Hand
foot and mouth disease
Liver injury
Inflammatory
Oxidative stress
