摘要
目的探讨前列腺癌组织中α-甲酰基辅酶A消旋酶(P504S)蛋白的表达与肿瘤特征及患者预后的关系。方法选取86例前列腺癌病理学组织标本作为前列腺癌组、90例前列腺增生组织作为良性组,应用免疫组化染色分析检测P504S蛋白在前列腺癌及前列腺增生组织中的差异。对比不同年龄、病灶大小、组织学分化程度、Gleason评分、TNM分期、前列腺癌特异性抗原(PSA)水平及淋巴结转移情况组织中P504S蛋白表达差异。采用Kaplan-Meier法分析P504S蛋白阳性与阴性患者2年的预后情况。结果前列腺癌组织中的P504S蛋白阳性表达率(68.60%)高于前列腺增生组织的24.44%,差异具有统计学意义(P<0.05)。在不同TNM分期、淋巴结转移、PSA水平的前列腺癌组织中的P504S蛋白阳性表达率差异具有统计学意义(P<0.05)。随访2年,P504S蛋白阳性表达组失访4例患者,P504S蛋白阳性表达患者的2年生存率为63.64%、低于阴性表达患者的81.48%,但差异无统计学意义(P>0.05)。经Kaplan-Meier法分析,P504S蛋白阳性表达患者的生存时间与阴性表达患者的生存时间差异无统计学意义(Log-rank(Mantel-Cox)=1.432,P=0.233>0.05)。结论前列腺癌P504S蛋白表达与肿瘤的发生发展具有一定的关系,但与患者2年生存预后关系尚不显著,可能需要延长随访时间进行进一步观察。
Objective To investigate the relationship between the expression ofα-formyl-CoA racemase(P504S)protein and tumor characteristics and prognosis in prostate cancer tissues.Methods 86 specimens of prostate cancer pathology collected were selected as prostate cancer group,90 cases of benign prostatic hyperplasia as benign group,and immunohistochemical staining analysis was used to detect P504S protein in prostate.Differences in cancer and benign prostatic hyperplasia,P504S protein expression in different ages,different lesion sizes,different histological differentiation,different Gleason scores,different TNM stages,different prostate cancer-specific antigens(PSA)levels,and lymph node metastasis Differences;Kaplan-Meier method was used to analyze the prognosis of P504S protein positive and negative patients for 2 years.Results The positive expression rate of P504S protein in prostate cancer tissues was 68.60%higher than that in benign prostatic hyperplasia(24.44%).The difference between the 2 groups was statistically significant(P<0.05).The prostate cancer was different in different TNM stages,different lymph node metastasis and different PSA levels.The positive expression rate of P504S protein in the tissues was statistically significant(P<0.05).After 2 years of follow-up,the P504S protein positive expression group was lost to 4 patients.The 2-year survival rate of P504S protein positive patients was 63.64%,negative expression.The patient had 81.48%,and the difference was not statistically significant(P>0.05).Kaplan-Meier analysis showed that there was no significant difference in survival time between patients with positive expression of P504S protein and survival time of patients with negative expression(Log-rank(Mantel-Cox)=1.432,P=0.233>0.05).Conclusion The expression of P504S protein in prostate cancer has a certain relationship with the occurrence and development of tumor,but it has no significant relationship with the prognosis of 2-year survival.It may be necessary to further extend the follow-up time for ob
作者
杨东
YANG Dong(Jiyuan People's Hospital,Jiyuan,459000)
出处
《实用癌症杂志》
2020年第9期1419-1422,共4页
The Practical Journal of Cancer
