摘要
目的探讨奥曲肽、垂体后叶素治疗肝硬化上消化道出血疗效。方法从该院2018年1月—2019年1月收治的肝硬化上消化道出血患者中,择取90例资料完备的患者作为研究对象。根据患者入组序号单双来进行分组,序号为单的45例患者,采取垂体后叶素治疗,设置为对照组;序号为双的45例患者,采取奥曲肽治疗,设置为观察组。对两组患者治疗总有效率、不良反应发生率进行统计,且记录两组患者的临床症状改善状况。结果观察组患者治疗总有效率为95.56%(43/45)明显高于对照组的71.11%(32/45),差异有统计学意义(χ^2=19.798,P<0.05)。观察组患者的不良反应发生率为6.67%(3/45)明显低于对照组的26.67%(12/45),差异有统计学意义(χ^2=12.994,P<0.05)。观察组患者的止血时间(16.2±0.3)h、腹痛消失时间(1.2±0.6)d相较于对照组的(25.3±0.8)h、(2.8±0.8)d,差异有统计学意义(t=71.447、10.730,P<0.05)。结论奥曲肽相较于垂体后叶素治疗肝硬化上消化道出血的临床效果更加优异,能够快速地改善患者临床症状,且安全性较高。
Objective To explore the therapeutic effect of octreotide and pituitary on the treatment of upper gastrointestinal bleeding in patients with liver cirrhosis.Methods From the patients with upper gastrointestinal hemorrhage of liver cirrhosis admitted in the hospital from January 2018 to January 2019,90 cases with complete data were selected as the research object.The patients were grouped according to the serial number of the patients.The 45 patients with the serial number were treated with pituitary and set as the control group;the 45 patients with the serial number were treated with octreotide and set as the observation group.The total effective rate of treatment and the incidence of adverse reactions of the two groups of patients were counted,and the improvement of clinical symptoms of the two groups of patients was recorded.Results The total effective rate of treatment in the observation group was 95.56%(43/45),which was significantly higher than that in the control group,71.11%(32/45).The difference was statistically significant(χ^2=19.798,P<0.05);The incidence of adverse reactions was 6.67%(3/45),which was significantly lower than that of the control group,26.67%(12/45),the difference was statistically significant(χ^2=12.994,P<0.05).Compared with the control group's(25.3±0.8)h and(2.8±0.8)d,the hemostatic time(16.2±0.3)h and abdominal pain disappearance time(1.2±0.6)d in the observation group were statistically significant difference(t=71.447,10.730,P<0.05).Conclusion Octreotide is more effective than pituitary in treating upper gastrointestinal hemorrhage of liver cirrhosis.It can quickly improve the clinical symptoms of patients and has high safety.
作者
李艳
LI Yan(Yicheng District People's Hospital,Zaozhuang,Shandong Province,277300 China)
出处
《系统医学》
2020年第15期4-6,共3页
Systems Medicine
关键词
奥曲肽
垂体后叶素
肝硬化上消化道出血
临床症状改善
不良反应
疗效
Octreotide
Posterior pituitary
Cirrhotic upper gastrointestinal bleeding
Clinical symptoms improved
Adverse reactions
Efficacy
