摘要
自噬是一种亚细胞过程,在溶酶体降解蛋白质受损细胞器如线粒体过程中发挥重要作用。它对蛋白质和线粒体功能的调节和维持细胞稳态至关重要,而其失调则涉及多种疾病,如动脉粥样硬化。最近有研究表明,无论动脉粥样硬化斑块中是否存在自噬刺激因子(例如活性氧、氧化脂质和细胞因子),动脉粥样硬化进展期间都存在自噬缺陷。本综述重点介绍了动脉粥样硬化自噬缺陷的原因和后果,特别是对巨噬细胞、血管平滑肌细胞和内皮细胞的影响,对治疗动脉粥样硬化的自噬靶标可能具有重要意义。
Autophagy is a subcellular process that plays an important role in the process of lysosomal degradation of protein-damaged organelles,such as mitochondria.It is essential for the regulation of functions of protein and mitochondria and the maintenance of cellular homeostasis.The disorder of autophagy is related to many diseases,such as atherosclerosis.Recent studies have shown that autophagy defects exist during the progression of atherosclerosis,regardless of the presence of autophagy stimulating factors(such as reactive oxygen species,oxidized lipids and cytokines)in atherosclerotic plaques.This review focuses on the causes and consequences of autophagy defects in atherosclerosis,especially the impact on macrophages,vascular smooth muscle cells and endothelial cells,which may be of great significance for the treatment of autophagy targets for atherosclerosis.
作者
李波
戴先鹏
LI Bo;DAI Xianpeng(Department of Vascular Surgery,the Second Hospital Affiliated to University of South China,Hengyang421001,China)
出处
《中国现代医生》
2020年第24期187-192,共6页
China Modern Doctor
基金
湖南省临床医疗技术创新引导项目(2018SK51501)。
关键词
动脉粥样硬化
自噬缺陷
巨噬细胞
血管平滑肌细胞
内皮细胞
细胞凋亡
衰老
Atherosclerosis
Autophagy defects
Macrophages
Vascular smooth muscle cells
Endothelial cells
Apoptosis
Senescence
