摘要
目的探讨早期实施个性化康复干预对于急性脑卒中患者的疗效及血清炎症因子的影响。方法选取2016年3月~2019年6月我院收治的51例急性脑卒中患者,随机分为对照组25例和观察组26例。观察组和对照组分别在病情稳定24 h和1周后展开康复治疗;采用NHISS量表、FMA量表和MBI量表分别评价两组患者治疗前后神经功能缺损情况、运动功能和日常生活能力;酶联免疫吸附实验测定患者治疗前后血清TNF-α、IL-1β和MCP-1水平。结果干预后,观察组患者的神经功能缺损评分显著低于对照组,而运动能力和日常生活能力均显著高于对照组,差异有统计学意义(P<0.05)。治疗前观察组和对照组血清TNF-α、IL-1β及MCP-1浓度间无显著差异,但治疗后观察组以上炎症因子较治疗前及和治疗后对照组比较均显著下降,差异有统计学意义(P<0.05)。结论早期实施个性化康复干预可改善急性脑卒中患者的疗效,并显著降低血清炎症因子水平。
Objective To investigate impacts of the early intervention of individualized rehabilitation on therapeutic efficacy and serum levels of inflammatory factors in patients with acute stroke.Methods Fifty-one patients with acute stroke admitted in our hospital from March 2016 to June 2019 were selected.They were randomly divided into the control group(n=25)and the observation group(n=26).Rehabilitation was conducted at 24 h and 1 week after patients remained stable condition.Baseline and post-treatment neurologic impairment,sports function and activity of daily living(ADL)in the two groups were assessed using the National Institute of Health Stroke Scale(NHISS),the Fugl-Meyer Assessment(FMA)and the modified Bathel index(MBI).Serum levels of tumor necrosis factor-α(TNF-α),interlukin-1β(IL-1β)and monocyte chemoattractant protein-1(MCP-1)before and after rehabilitation were detected using an enzyme-linked immunosorbent assay(ELISA).Results NHISS scores for neurologic impairment were lower and FMA and MBI scores for sports function and ADL were higher in the observation group than those in the control group after rehabilitation,with statistically significant differences(P<0.05).There were no significant differences in baseline levels of TNF-α,IL-1βand MCP-1 between the observation group and the control group.Serum levels of the three indices decreased after early rehabilitation in the observation group both compared with its baseline levels and the control group,with statistically significant differences(P<0.05).Conclusion The early intervention of individualized rehabilitation can facilitate the therapeutic efficacy in acute stroke,reduced serum levels of inflammatory factors.
作者
李志勇
鞠雅兵
杨志鹏
LI Zhiyong;JU Yabing;YANG Zhipeng(Department of Sports Medicine and Rehabilitation,Jiujiang No.1 People's Hospital in Jiangxi Province,Jiujiang 332000,China;Department of Clinical Laboratory,Jiujiang Chinese Medicine Hospital in Jiangxi Province,Jiujiang 332000,China;Department of Emergency,Jiujiang No.1 People's Hospital in Jiangxi Province,Jiujiang332000,China)
出处
《中国现代医生》
2020年第24期10-12,16,共4页
China Modern Doctor
关键词
个性化康复
急性脑卒中
疗效
炎症因子
Individualized rehabilitation
Acute stroke
Therapeutic efficacy
Inflammatory factors
