摘要
CO是一种生物体中广泛存在的气体信号分子,具有抗炎、抑制肿瘤细胞增殖和抗菌等生理功能。由于直接吸入CO存在中毒的风险且难以实现病理组织富集等问题,近年来,研究人员发展了多种一氧化碳释放分子(CORMs)。这些供体分子能够在特定的环境下释放CO,作为CO气体的替代品而展现出潜在的应用前景。然而传统的CORMs均为小分子,它们普遍在生物环境中存在稳定性不足、半衰期短和生物分布不佳等问题。针对上述问题,通过将CORMs物理负载或者化学键合到高分子材料中,成功制备的多种CO释放大分子相对于CORMs小分子前体而言,不仅能够有效增强稳定性和延长释放时间,而且对病理组织具有一定的靶向性,对相关疾病展现出更优异的治疗潜能。综述了CO释放大分子的研究进展,并对这一新兴领域的发展方向进行了展望。
Carbon monoxide(CO)is a gaseous transmitter that has received mounting interest because of its therapeutic potentials in the treatment of inflammation,bacterial infection,cancer and so on.However,the clinical application of CO is remarkably hindered by the difficulty in precisely controlling CO concentrations and the targeted delivery of CO to pathological tissues.To circumvent these problems,CO-releasing molecules(CORMs)have been developed and widely used as the alternative of gaseous CO to explore the physiological functions of CO and develop novel therapeutic agents.Unfortunately,conventional CORMs suffered from insufficient stability,short half-life,and poor biodistribution in biological conditions.Intriguingly,the encapsulation of CORMs into polymeric nanoparticles or covalently installation of CORMs to polymeric matrices remarkably improves the stability of CORMs,prolongs the releasing time and optimizes the biodistributions.In this review,we summarize the recent achievements of CO-releasing macromolecules and highlight three approaches used for the fabrication of CO-releasing macromolecules.Also,we envision the potential applications of these macromolecular CO donors and suggest future directions in this field.We hope that more efforts would be devoted to this emerging field to advance the clinical trial of macromolecular CO donors.
作者
张名扬
程健
胡进明
ZHANG Mingyang;CHENG Jian;HU Jinming(CAS Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China)
出处
《功能高分子学报》
CAS
CSCD
北大核心
2020年第5期421-432,共12页
Journal of Functional Polymers
基金
国家自然科学基金(51690150,51690154,51722307,51673179)
中央高校基本科研业务专项基金(WK3450000003)。
关键词
一氧化碳
气体信号分子
一氧化碳释放分子
高分子纳米载体
carbon monoxide
gaseous transmitters
carbon monoxide-releasing molecules(CORMs)
macromolecular nanovectors
