摘要
目的利用网络药理学研究方法预测BBR干预DA的作用机制。方法利用TCMSP数据库、CTD数据库,挖掘BBR的作用靶点,通过DisGeNET、GeneCards、OMIM等数据库筛选出DA的靶标。运用Cytoscape软件构建BBR干预DA的“成分-靶标-疾病”网络,通过STRING数据库构建靶点蛋白相关作用网络并进行关键靶点的生物功能注释及通路分析。结果BBR可以通过干预228个靶点、38条通路干预DA。结论BBR可能通过抑制炎性反应、保护内皮细胞等药理作用干预DA。
Objective To predict the mechanism of berberine in the treatment of diabetic atherosclerosis by using the method of network pharmacology.Methods TCMSP and CTD database were used to mine the targets of berberine.The target of diabetic atherosclerosis was screened out by DisGeNET,GeneCards and OMIM.Cytoscape software was used to construct the“component-target-disease”network for the treatment of atherosclerosis obliterans.The target protein-related action network was constructed by STRING database,and the biological function annotation and pathway analysis of the key targets were carried out.Results Berberine could treat diabetic atherosclerosis by acting on 228 targets and involving 38 pathways.Conclusion Berberine may treat diabetic atherosclerosis by inhibiting the inflammatory reaction and protecting endothelial cells.
作者
李爱玲
庞雪
王玉涛
LI Ailing;PANG Xue;WANG Yutao(Department of Endocrinology,Tengzhou Traditional Chinese Medicine Hospital,Zaozhuang 277599,Shandong,China;Department of Colorectal Surgery,Shandong Provincial Qianfoshan Hospital,Jinan 250014,Shandong,China;Department of Peripheral Vascular Disease,Jinan Municipal Hospital of Traditional Chinese Medicine,Jinan 250012,Shandong,China)
出处
《辽宁中医杂志》
CAS
2020年第7期137-139,I0004,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
山东省中医药科技发展计划(2017-299,2019-0660)
山东省医药卫生科技发展计划(2018WS478)
济南市第二届优秀卫生计生人才培养项目(济卫科外发[2018]8号)
济南市第三批“薪火传承231工程”培养项目(济中医药发[2017]11号)
张恒龙山东省名老中医药专家传承工作室建设项目(鲁卫中发展字[2018]1号)
迟景勋全国名老中医药专家传承工作室建设项目(国中医药人教发[2016]42号)。
