摘要
目的探讨子宫内膜癌的复发情况.方法对2000—2012年期间广东地区64家子宫内膜癌防治项目协作医院收集到的5816例子宫内膜癌病例进行回顾性分析.结果(1)5816例子宫内膜癌患者中,3、5、10年无进展生存率为90.7%、89.5%、88.5%,其中复发病例689例,占11.8%,复发时间3~101个月,中位复发时间12个月;术后1年内复发占51.1%;术后5年内复发者占97.8%.(2)复发部位最常见于盆腔(58.8%)、肺(18.1%)、骨(10.5%).(3)Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者的5年无进展生存率分别为94.0%、89.4%、72.1%、38.8%,Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者的复发率分别为6.6%、14.2%、29.8%、56.0%,随着手术-病理分期增高,子宫内膜癌患者复发率增高.(4)子宫内膜样腺癌、浆液性腺癌、透明细胞癌、鳞状细胞癌的复发率分别为11.3%、29.7%、24.6%、35.7%,Ⅱ型子宫内膜癌的复发率比Ⅰ型子宫内膜癌高.结论子宫内膜癌复发率仍较高,子宫内膜癌术后应严格随访至术后5年,随访重点筛查盆腔情况,同时应该加强晚期和特殊类型患者的治疗和随访.
Objective To analyze independent prognostic factors of endometrial cancer.Methods We retro-spective analyze clinical pathologic data of 5,816 patients who were diagnosed with endometrial cancer from 2000 to 2012 in hospitals of endometrial cancer prevention projects in Guangdong Province.Results(1)The 3-year,5-year,10-year overall progression-free survivals of the 5,816 patients with endometrial cancer were 90.7%,89.5%and 88.5%,respectively.The recurrence was observed in 689 cases among the 5,816 cases,and the recurrence rate was 11.8%.Re-currence time were 3 to 101 months,and the median recurrence time was 12 months.Among them,51.1%patients re-lapsed within 3 years,and 97.8%patients relapsed within 5 years.(2)The most common recurrence place was pelvic(58.8%),lung(18.1%)and bone(10.5%).(3)The 5-year overall progression-free survivals of patients with en-dometrial cancer StageⅠ,Ⅱ,ⅢandⅣwere 94.0%,89.4%,72.1%and 38.8%,respectively.The recurrence rates of patients with endometrial cancer StageⅠ,Ⅱ,ⅢandⅣwere 6.6%,14.2%,29.8%,and 56.0%,respectively.The recurrence rate in patient with endometrial cancer increased with the increasing stage.(4)The recurrence rates of en-dometrioid adenocarcinoma,serous adenocarcinoma,clear cell carcinoma,and squamous cell carcinoma were 11.3%,29.7%,24.6%,and 35.7%,respectively.Conclusion The recurrence rate of endometrial cancer remaines high.En-dometrial cancer patients should be strictly followed up for at least 5 years after surgery.Follow-up should focus on screening for pelvic conditions.And the treatment and follow-up of patients with advanced stages and special types should be strengthened.
作者
杨晓辉
欧阳婧
李小毛
YANG Xiao-hui;OUYANG Jing;LI Xiao-mao(Department of Gynecology,the Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630,Guangdong,China)
出处
《广东医学》
CAS
2020年第16期1647-1650,共4页
Guangdong Medical Journal
基金
广东省妇幼安康工程—子宫内膜癌防治项目。
关键词
子宫内膜癌
复发
临床分析
endometrial cancer
recurrence
clinical analysis
