摘要
双酚A(BPA)是一种公认的环境内分泌干扰物,具有类雌激素效应,在工业上它被广泛用来合成聚碳酸酯和环氧树脂等材料。由于大量的研究证实了BPA的生物毒性作用,BPA的生产和使用受到严格限制,因此,一些BPA替代品如双酚F、双酚S和双酚AF逐渐被开发出来且广泛应用于各类消费产品中。随着BPA及其类似物的大规模生产和使用,几乎在所有的环境介质中和部分人体生物样本中都能够检出BPA及其类似物。因此,这些新的替代品是否安全亟须研究。近些年,随着研究的不断深入,BPA类似物被证实对生物具有多种毒性效应。本文综述了国内外BPA及其类似物的环境污染和人体暴露状况,及其生物毒性效应,包括急性毒性、内分泌干扰、神经毒性、生殖与发育毒性、心血管毒性和细胞与基因毒性等方面,并对今后BPA类似物的研究方向进行了展望。
Bisphenol A(BPA)is a recognized environmental endocrine disruptor with estrogenic-like effects.It is widely used in industry to synthesize materials such as polycarbonate and epoxy resin.Because a large number of studies have confirmed the biological toxicity of BPA,the production and use of BPA are strictly restricted.Therefore,some substitutes of BPA,such as bisphenol F,bisphenol S,and bisphenol AF,have been gradually developed and widely used in various consumer products.With the large-scale production and use,BPA and its analogues can be detected in almost all environmental media and some human biological samples.Therefore,it is urgent to study whether these new substitutes are safe or not.In recent years,with the development of relevant research,BPA analogues have been proved to have a variety of toxic effects on organisms.This paper summarized the environmental pollution of and human exposure to BPA and its analogues at home and abroad.Their biological toxic effects were reviewed as well,including acute toxicity,endocrine interference effect,neurotoxicity,reproductive and developmental toxicity,cardiovascular toxicity,cytotoxicity,and genotoxocity.Future research perspects of BPA analogues were discussed.
作者
顾杰
吉贵祥
周林军
古文
葛海虹
GU Jie;JI Gui-xiang;ZHOU Lin-jun;GU Wen;GE Hai-hong(Nanjing Institute of Environmental Sciences,MEE,Nanjing,Jiangsu 210042,China;Solid Waste and Chemicals Management Center,MEE,Beijing 100029,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2020年第8期826-831,F0004,共7页
Journal of Environmental and Occupational Medicine
基金
中央级公益性科研院所基本科研业务专项(GYZX200102)。
关键词
双酚A
双酚类似物
环境分布
毒性效应
bisphenol A
bisphenol analogues
environmental distribution
toxic effect
