摘要
目的研究盆腔子宫内膜异位症患者行冻融胚胎复苏移植(FET)采用不同内膜准备方案对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法回顾性分析2016年1月1日至2018年12月31日在我院生殖医学中心采用FET的盆腔子宫内膜异位症患者,周期数共1170例,根据内膜准备方案不同分为:自然周期内膜准备组(A组)和Gn RH-a降调节周期内膜准备组(B组)。回顾性分析两组患者的一般资料、复苏周期移植情况及妊娠结局等。结果两组患者年龄、不孕年限等一般临床资料组间差异均无统计学意义(P>0.05)。A组患者的生化妊娠率、临床妊娠率、着床率及活产率均高于B组(P<0.05),而多胎妊娠率、流产率、异位妊娠率、早产率、新生儿体质量及身长等比较,差异均无统计学意义(P>0.05)。通过Logistic回归对影响活产率的因素进行分析,结果显示患者年龄、AMH、移植优质囊胚个数以及不同的内膜准备方案对活产率有影响(P<0.05)。结论与降调节周期内膜准备相比,盆腔子宫内膜异位症患者行FET时,采用自然周期内膜准备可提高着床率,临床妊娠率和活产率,减少患者的经济负担和药物使用,是更理想的内膜准备方案。
Objective To study the effects of different endometrial preparation protocol in endometriosis patients undergoing frozen-thawed embryo transfer( FET) on the pregnancy outcome of in vitro fertilization-embryo transfer( IVF-ET). Methods From January 1,2016 to December 31,2018,1170 patients who were diagnosedas endometriosis treated by FET at our reproductive medical center were included. According to different endometrial preparation protocol,they were divided into natural cycle endometrial preparation group( A group) and Gn RH-a down regulation cycle endometrial preparation group( Bgroup). Baseline characteristic,and pregnancy outcome were retrospectively analyzed.Results There were no significant differences in baseline characteristic data such as ages,infertility duration and so on( P>0.05).The biochemical pregnancy rate,clinical pregnancy rate,implantation rate and live birth rate of A group were significantly higher than those of B group( P< 0.05),but there were no significant differences in multiple birth rate,abortion rate,ectopic pregnancy rate,preterm birth rate,newborn weight and height( P>0.05).Logistic regression analysis showed that age,AMH,high-quality blastocysts transplanted number and endometrial preparations protocol were related to live birth rate( P< 0.05). Conclusion Compared to Gn RH-a down regulationcycle endometrial preparation,when endometriosis patients undergo FET,natural cycle endometrial preparation could improveimplantation rate,clinical pregnancy rate and live birth rate,which is a more ideal method in dinical practice.
作者
李亚
钟菁
刘敬
王莉莉
饶津宁
谭世桥
钟影
Li Ya;Zhong Jing;Liu Jing(Center of Reproductive Medicine,Chengdu Xi nan Gynecology Hospital,Chengdu,Sichuan 610066,China)
出处
《四川医学》
CAS
2020年第8期868-873,共6页
Sichuan Medical Journal
关键词
盆腔子宫内膜异位症
冻融胚胎复苏移植
自然周期内膜准备
降调节周期内膜准备
临床妊娠率
活产率
endometriosis
frozen-thawed embryo transfer
natural cycle endometrial preparation
Gn RH-a down regulationcycle endometrial preparation
clinical pregnancy rate
live birth rate
