摘要
目的探究产妇血清、唾液及乳汁乙型肝炎病毒(HBV)-脱氧核糖核酸(DNA)载量与感染状态相关性及新生儿HBV感染率的影响因素,以降低新生儿HBV感染。方法选取2017年5月1日-2019年7月31日某院126例HBV携带产妇及其新生儿作为研究对象,根据产妇HBV感染状态分为大三阳组(42例)、小三阳组(42例)、单纯阳性组(无任何症状表现的病毒携带者,42例)。检测对比3组产后血清、唾液、乳汁HBV-DNA载量,统计3组新生儿HBV感染率,分析血清、唾液、乳汁HBV-DNA载量与产妇感染状态关联性及新生儿HBV感染影响因素。结果 3组产后血清、唾液、乳汁HBV-DNA载量比较,由高到低依次为大三阳组、小三阳组、单纯阳性组,血清、唾液、乳汁HBV-DNA载量与感染状态呈正相关(P<0.05);大三阳组新生儿HBV感染率高于小三阳组、单纯阳性组,小三阳组高于单纯阳性组(P<0.05);孕前BMI>24.0 kg/m^2、胎盘HBsAg阳性及血清、唾液、乳汁HBV-DNA载量高均为新生儿HBV感染的独立危险因素(P<0.05)。结论产妇血清、唾液及乳汁HBV-DNA载量与感染状态呈明显正相关关系,且是新生儿HBV感染的独立危险因素,产前应加强抗HBV治疗,降低HBV-DNA载量,且产后应尽量避免母乳喂养,以降低新生儿HBV感染率。
Objectives To investigate the relationship between maternal serum, saliva and milk hepatitis B virus(HBV)-deoxyribonucleic acid(DNA) load and infection status and its effect on the incidence of neonatal HBV infection. To reduce neonatal HBV infection. Methods 126 HBV-bearing mothers and her newborn in our hospital from May 1 st,2017 to July 31 st,2019 were selected as subjects, and according to the HBV infection status, they were divided into the big three positive group(42 cases), the small three positive group(42 cases), and the simple positive group(viral carriers without any symptoms, 42 cases). The HBV-DNA load of serum, saliva and milk in the three groups was measured and compared. The HBV infection rate of the three groups was analyzed. The correlation between serum, saliva, milk HBV-DNA load and maternal infection status and the influencing factors of neonatal HBV infection were analyzed.Results The HBV-DNA load of postpartum serum, saliva, and milk were compared among the three groups, from high to low, they were in the big three positive group, the small three positive group, and the simple positive group, the HBV-DNA load of serum, saliva and milk were positively correlated with the infection status(P<0.05);the HBV infection rate of neonates in the big three positive group was higher than that in the small three positive group and the simple positive group, and the small three positive group was higher than the simple positive group(P<0.05);pre-pregnancy BMI >24.0 kg/m^2, positive HBsAg in placenta and high HBV-DNA load in serum, saliva, and milk were all independent risk factors for neonatal HBV infection(P<0.05).Conclusions The HBV-DNA load of maternal in serum, saliva and milk was significantly positively related to the infection status, and was an independent risk factor for HBV infection in newborns, and anti-HBV treatment should be strengthened before delivery to reduce HBV-DNA load, and breastfeeding should be avoided as far as possible to reduce the HBV infection rate in newborns.
作者
徐永琴
邹奕
邹泽均
谢明月
张方芳
阴敏
Xu Yongqin;Zou Yi;Zou Zejun;Xie Mingyue;Zhang Fangfang;Yin Min(Panzhihua Maternal and Child Health Hospital,Panzhihua 617000,Sichuan Province,China)
出处
《中国病案》
2020年第7期105-109,共5页
Chinese Medical Record
