摘要
目的:探索达格列净联合二甲双胍对老年2型糖尿病(T2DM)患者血糖水平及心血管危险因素的影响。方法:选取2018年3月至2019年3月我院就诊的老年T2DM患者100例进行研究,按照随机数字表法随机分为试验组和对照组,各50例,对照组给予二甲双胍治疗,试验组在对照组的基础上加用达格列净治疗,治疗6个月后比较两组血糖及心血管危险因素(包括血脂、血压及炎性因子)变化。结果:治疗6个月后,试验组患者空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、24 h平均血压值(24 h SBP)、24 h平均舒张压力(24hDBP)、白天平均收缩压(dSBP)、白天平均舒张压(dDBP)、夜间平均收缩压(nSBP)、夜晚平均舒张压(nDBP)、同型半胱氨酸(Hcy)、C反应蛋白(CRP)、甘露糖结合凝集素(MBL)及基质金属蛋白酶(MMP-9)水平均显著低于对照组(P<0.05);试验组患者高密度脂蛋白胆固醇(HDL-C)水平显著高于对照组(P<0.05);两组不良反应率差异无统计学意义(P<0.05)。结论:达格列净联合二甲双胍对老年T2DM患者降糖效果显著,可有效改善和调节患者心血管危险因素相关指标水平,具有推荐应用价值。
Objective:To investigate the effects of Daglitazone combined with Metformin on blood glucose level and cardiovascular risk factors in elderly patients with type 2 diabetes mellitus(T2DM).Methods:A total of 100 elderly T2DM patients admitted to our hospital between March 2018 and March 2019 were included in the study.All patients were randomly divided into the study group and control group(n=50 each).The control group was treated with Metformin.In addition,the study group was treated with Daglitazone.At 6 months after the treatment,the changes in blood glucose and cardiovascular risk factors(including blood lipids,blood pressure and inflammatory factors)were compared between the two groups.Results:At 6 months after the treatment,the levels of fasting blood glucose(FPG),2h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),24h systolic blood pressure(24hSBP),24h diastolic blood pressure(24hDBP),daytime systolic blood pressure(dSBP),daytime diastolic blood pressure(dDBP),nighttime systolic blood pressure(nSBP),nighttime diastolic blood pressur(nDBP),homocysteine(Hcy),C-reactive protein(CRP),mannose-binding lectin(MBL)and matrix metalloproteinase(MMP-9)in the study group were significantly lower than those in the control group(all P<0.05).The level of high-density lipoprotein cholesterol(HDL-C)in the study group was significantly higher than that in the control group(P<0.05).There was no statistically significant difference in adverse reaction between the two groups(P<0.05).Conclusion:Daglitazone combined with Metformin show a significant hypoglycemic effect in elderly patients with T2DM.It may effectively improve and regulate the levels of cardiovascular risk factors related indexes,and is therefore recommended.
作者
黄小区
潘洁婷
邝恒幸
蔡杰
苏美霞
Huang Xiaoqu;Pan Jieting;Kuang Hengxing;Cai Jie;Su Meixia(Department of Pharmacy,Zhanjiang Central People’s Hospital,Zhanjiang,Guangdong 524045,China)
出处
《广州医科大学学报》
2020年第4期24-28,共5页
Academic Journal of Guangzhou Medical University
关键词
达格列净
二甲双胍
血糖
心血管危险因素
Daglitazone
Metformin
blood glucose
cardiovascular risk factors
