摘要
脂肪沉积与代谢具有明显的性别差异,类固醇激素在其中扮演着重要的角色。脂肪细胞中类固醇激素代谢转化依赖众多类固醇激素代谢酶的参与,类固醇激素代谢酶的时空特异性激活对调控脂肪分布与脂质代谢具有重要意义。该文针对脂肪组织中11β羟基类固醇脱氢酶、17β羟基类固醇脱氢酶、3α羟基类固醇脱氢酶、3β羟基类固醇脱氢酶、5α还原酶、芳香化酶、类固醇硫酸酯酶、类固醇合成快速调节蛋白等类固醇激素代谢中的关键酶进行综述,阐述雄激素在脂肪细胞中的代谢机制,进一步解析其作用的复杂原因,为今后动物体脂沉积和人类脂肪代谢相关疾病研究提供一定的科学依据。
There are obvious gender differences in fat deposits and metabolism,which steroid hormones play an important role.Steroid hormone metabolism and transformation in adipocytes depends on the participation of many steroid hormone metabolic enzymes.The spatiotemporal specific activation of steroid hormone metabolic enzymes is of great significance to regulate fat distribution and lipid metabolism.The aim of this review was to present the function of steroid hormone metabolic enzymes in adipose tissues,including HSD17B1,HSD17B2,17b-HSD type 2,17b-HSD type 3,17b-HSD type 3(AKR1C3),3α-HSD,3β-HSD,5a-reductases,Aromatase,Steroid sulfatase,StAR,and further analyzed its complex mechanisms,providing a useful reference for the researches on the fat deposits of animal and on the diseases associated with lipid metabolism disorders in human.
作者
赵海东
邬明丽
王淑辉
孙秀柱
ZHAO Haidong;WU Mingli;WANG Shuhui;SUN Xiuzhu(College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China)
出处
《家畜生态学报》
北大核心
2020年第8期79-84,共6页
Journal of Domestic Animal Ecology
基金
陕西省自然科学基础研究计划青年人才项目(2015JQ3072)
杨凌示范区产学研用协同创新重大项目(2016CXY-15)
陕西省重点研发计划(2018ZDXM-NY-040)。
关键词
脂肪沉积
类固醇激素
类固醇激素代谢酶
fat deposits
steroid hormone
metabolic enzymes of steroid hormone
