摘要
目的观察艾灸联合体外冲击波碎石术(ESWL)治疗输尿管结石的临床疗效。方法 100例输尿管结石患者,采取随机数字表将其分成观察组和对照组,每组50例。对照组行ESWL治疗,观察组在对照组治疗基础上联合艾灸治疗。观察两组治疗前后半胱氨酸蛋白酶抑制剂C(Cys-C)、肾小球滤过率(GFR)水平、血清肌酐(Scr)、中性粒细胞明胶酶相关载脂蛋白(NGAL)的变化,并比较两组结石排净率、肾绞痛发生率、结石排出时间、血尿持续时间和临床疗效。结果观察组总有效率为96.0%,对照组为86.0%,观察组总有效率明显高于对照组(P<0.05)。观察组的结石排净率为96.0%,明显高于对照组的84.0%(P<0.05);观察组肾绞痛发生率为6.0%,明显低于对照组的20.0%(P<0.05)。观察组结石排出时间、血尿持续时间均显著短于对照组(P<0.01)。两组术后2 h、术后1 d血清NGAL、Cys-C水平逐渐升高(P<0.01),GFR逐渐下降(P<0.01),术后3 d上述指标逐渐恢复;观察组术后1 d、3 d Cys-C、NGAL水平明显低于对照组(P<0.01),GFR明显高于对照组(P<0.01)。两组术前术后各时点血清Scr水平比较差异无统计学意义(P>0.05)。结论艾灸联合ESWL治疗输尿管结石疗效显著,并能降低体外冲击波治疗引起的肾损伤。
Objective To observe the clinical efficacy of moxibustion plus extracorporeal shock wave lithotripsy(ESWL)in treating urethral calculus.Method One hundred patients with urethral calculus were divided into an observation group and a control group using the random number table method,with 50 cases in each group.The control group received ESWL,while the observation group was given additional moxibustion treatment.The post-treatment changes in cystatin C(Cys-C),glomerular filtration rate(GFR),serum creatinine(Scr)and neutrophil gelatinaseassociated lipocalin(NGAL)were observed in the two groups;the stone-free rate,incidence of renal colic,stone elimination time,hematuria lasting time and clinical efficacy were compared between the two groups.Result The total effective rate was 96.0%in the observation group versus 86.0%in the control group,and the total effective rate was significantly higher in the observation group than in the control group(P<0.05).The stone-free rate was 96.0%in the observation group,markedly higher than 84.0%in the control group(P<0.05);the incidence of renal colic was 6.0%in the observation group,significantly lower than 20.0%in the control group(P<0.05).The stone elimination time and hematuria lasting time were significantly shorter in the observation group than in the control group(P<0.01).Respectively at 2 h and 1 d after operation,the serum levels of NGAL and Cys-C gradually increased in both groups(P<0.01)while the GFR dropped gradually(P<0.01);3 d after operation,the above indexes were gradually restored.One day and 3 d after operation,the levels of Cys-C and NGAL in the observation group were significantly lower than those in the control group(P<0.01),and the GFR was significantly higher in the observation group than in the control group(P<0.01).There were no significant differences in the serum level of Scr between the two groups before and after operation(P>0.05).Conclusion Moxibustion plus ESWL can produce significant efficacy in treating urethral calculus and reduce renal injuries caus
作者
那尔布力·巴合提别克
阿斯木江·阿不拉
Naerbuli Bahetibieke;Asimujiang Abula(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《上海针灸杂志》
2020年第9期1104-1108,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
新疆维吾尔自治区自然科学基金自治区创新环境(人才、基地)建设专项(自然科学基金)联合基金项目(2019D01C314)。
