摘要
目的:探讨多囊卵巢综合征(PCOS)患者血清人附睾蛋白4(HE4)对子宫内膜增生的预测价值。方法:选取2016年3月—2018年12月因不孕症或子宫不规则出血在本院行诊刮术的PCOS患者198例作为PCOS组,同时期因输卵管或男性因素致不孕而行诊刮术患者203例作为对照组。电化学发光免疫分析法检测两组血清HE4水平。采用多因素logistic回归分析影响子宫内膜增生的因素。采用受试者工作曲线(ROC)评估HE4预测PCOS患者发生子宫内膜增生病变的预测价值。结果:多因素logistic回归模型分析发现,体质指数[OR(95%CI):1.46(1.25~1.72)]、空腹血糖[OR(95%CI):1.31(1.17~1.48)]、低密度脂蛋白[OR(95%CI):1.12(1.06~1.19)]、雌二醇[OR(95%CI):1.24(1.13~1.36)]和HE4[OR(95%CI):1.29(1.13~1.46)]均是PCOS患者发生子宫内膜增生的危险因素。ROC曲线分析,HE4预测PCOS患者发生子宫内膜增生病变的最佳临界点为102.93 pmol/L,此时HE4预测灵敏度为77.3%,特异度为97.3%,曲线下面积0.830。结论:HE4与PCOS患者子宫内膜增生病变显著相关,可作为预测PCOS患者子宫内膜增生病变的生物标志物。
Objective:To investigate the value of human epididymal protein 4(HE4)level for predicting endometrial hyperplasia of women with polycystic ovary syndrome(PCOS).Methods:From March 2016 to December 2018,198 women with PCOS who had undergone curettage due to infertility or irregular uterine bleeding were selected in study group.And 203 infertility women with who had undergone curettage caused by fallopian tube or male factors were included in control group.The level of serum HE 4 was measured by electrochemiluminescence immunoassay.Multivariate logistic regression was used to analyze the potential factors affected endometrial hyperplasia.The receiver operating characteristic(ROC)was used to evaluate the value of HE4 for predicting endometrial hyperplasia of women with PCOS.Results:Multivariate logistic regression model suggested that BMI[OR(95%CI):1.46(1.25-1.72)],the value of FBG[OR(95%CI):1.31(1.17-1.48)],the LDL level[OR(95%CI):1.12(1.06-1.19)],the E2 level[OR(95%CI):1.24(1.13-1.36)],and the HE4 level[OR(95%CI):1.29(1.13-1.46)]were the independent risk factors of endometrial hyperplasia of women with PCOS.ROC curve showed that the best cut-off value of HE4 level for predicting endometrial hyperplasia in PCOS patients was 102.93 pmol/L,which’s sensitivity,specificity,and the area under curve(AUC)were 77.31%,97.34%,and 0.830,respectively.Conclusion:HE4 is significantly correlated with endometrial hyperplasia of women with PCOS,which can be used as a biomarker to predict endometrial hyperplasia of women with PCOS.
作者
徐静
齐瑞玲
高亚南
XU Jing;QI Ruiling;GAO Yanan(Luohe Central Hospital, Henan Province,462000)
出处
《中国计划生育学杂志》
2020年第8期1278-1281,共4页
Chinese Journal of Family Planning
关键词
多囊卵巢综合征
子宫内膜增生
人附睾蛋白4
预测价值
Polycystic ovary syndrome
Endometrial hyperplasia
Human epididymal protein 4
Predictive value
