摘要
目的:探讨儿童急性淋巴细胞白血病并发感染治疗中静脉输注丙种球蛋白的效果及对小儿生活质量(quality of life,QOL)评分的影响.方法:选取2016年8月-2019年8月于本院住院治疗的急性淋巴细胞白血病并发感染的患儿68例,按治疗方式分为对照组与研究组,各34例.对照组予以抗生素治疗,研究组在对照组基础上予以静脉输注丙种球蛋白治疗.比较两组感染控制情况、治疗前后心理状态及QOL评分.结果:研究组感染控制情况优于对照组(P<0.05).治疗后,研究组焦虑自评量表(self-rating anxiety scale,SAS)与抑郁自评量表(self-rating depression scale,SDS)评分均低于对照组(P<0.05).治疗后,两组各项QOL评分均高于治疗前(P<0.05);研究组各项QOL评分均高于对照组(P<0.05).结论:静脉输注丙种球蛋白治疗急性淋巴细胞白血病并发感染患儿的效果较好,改善患儿心理状态,提升生活质量,值得临床推广应用.
Objective:To investigate the effect of intravenous injection of Gamma Globulin in the treatment of acute lymphoblastic leukemia complicated with infection and its influence on the quality of life(QOL)score in children.Method:A total of 68 children with acute lymphoblastic leukemia complicated with infection hospitalized in our hospital from August 2016 to August 2019 were selected.They were divided into control group and study group according to treatment methods,34 cases in each group.The control group was treated with antibiotics,and the study group was treated with intravenous injection of Gamma Globulin on the basis of the control group.Infection control,psychological status and QOL score before and after treatment were compared between the two groups.Result:The infection control of the study group was better than that of the control group(P<0.05).After treatment,the scores of self-rating anxiety Scale(SAS)and self-rating Depression Scale(SDS)in the study group were lower than those in the control group(P<0.05).After treatment,QOL scores of both groups were higher than those before treatment(P<0.05).After treatment,all QOL scores in the study group were higher than those in the control group(P<0.05).Conclusion:The therapeutic effect of intravenous injection of Gamma Globulin in children with acute lymphoblastic leukemia complicated with infection is better.It can improve the psychological state and quality of life of the children,which is worthy of clinical application.
作者
黎巧茹
赖文英
林春燕
李丽羽
朱蔼欣
陈琼
黄春辉
LI Qiaoru;LAI Wenying;LIN Chunyan;LI Liyu;ZHU Aixin;CHEN Qiong;HUANG Chunhui(Zhongshan People’s Hospital,Zhongshan 528400,China)
出处
《中国医学创新》
CAS
2020年第19期68-71,共4页
Medical Innovation of China
基金
中山市社会公益科技研究项目(2018B1058)。
关键词
急性淋巴细胞白血病并发感染
静脉输注丙种球蛋白
Acute lymphoblastic leukemia complicated with infection
Intravenous injection of Gamma Globulin
