摘要
目的探讨颗粒细胞瘤(GCT)的临床及病理学特征。方法回顾性分析37例颗粒细胞瘤的临床资料、组织学形态及免疫组化染色结果,收集随访资料并复习文献。结果37例中女性23例,男性14例,年龄13~74岁,平均42岁,以食管、胸腹壁等部位好发,多无明显症状;组织学上瘤细胞多边形或卵圆形,胞质丰富,嗜酸性颗粒状,可见脓疱卵形小体,核小而圆,排列呈巢状或片状,细胞巢间为宽窄不等的胶原化纤维性间隔。免疫组化示S-100、CD68和NSE(+)。参照Fanburg-Smith等提出的6项诊断标准判断,良性颗粒细胞瘤34例、不典型颗粒细胞瘤1例、恶性颗粒细胞瘤2例,其中多发性颗粒细胞瘤3例。25例有随访资料,23例无复发,1例肝、淋巴结转移,1例多次复发后肝转移。结论颗粒细胞瘤大多属于良性肿瘤,少数为多发性,恶性罕见。恶性颗粒细胞瘤的诊断可采用Gamboa分型结合Fanburg-Smith标准。
Objective To investigate the clinicopathologic features of granular cell tumor(GCT).Methods The clinical and pathologic profiles of 37 cases were retrospectively analysed and literatures were reviewed.Results 37 cases involved 14 male and 23 female patients,with an average age of 42 years,usually presenting as a single asymptomatic lesion,mainly located in esophagus and thoracoabdominal wall.The tumor cells were polygonal or oval,with abundant eosinophilic,granular cytoplasm and pustulo-ovoid bodies,arranged in sheets,nests,cords or trabeculae,expressed S-100,CD68 and NSE by immunohistochemical staining.According to Fanburg-Smith criteria,34 cases were diagnosed as benign GCT,1 case was atypical GCT and 2 cases were malignant GCT,among them 3 cases were multiple GCT.25 patients had follow-up data,23 had no recurrence,1 had hepatic and lymph node metastasis,and 1 recurred repeatedly.Conclusion Granular cell tumors are almost benign,some are multiple,malignant GCTs are extremely rare.Gamboa grouping combined with Fanburg-Smith criteria has a good application in the diagnosis of malignant GCT.
作者
房惠琼
张良运
刘芳
王路祎
FANG Hui-qiong;ZHANG Liang-yun;LIU Fdrig;WANG Lu-yi(Department of Pathology,the First People's Hospital of Foshan,Foshan 528000,China)
出处
《诊断病理学杂志》
2020年第7期459-462,467,共5页
Chinese Journal of Diagnostic Pathology
关键词
颗粒细胞瘤
免疫组化
病理学
诊断标准
Granular cell tumor
Immunohistochemistry
Pathology
Diagnostic criteria
