摘要
目的:探究含左氧氟沙星方案治疗复治肺结核患者的临床效果及对血清干扰素-γ(interferon-γ,IFN-γ)和骨桥蛋白(osteopontin,OPN)的影响。方法:选取2018年1月-2019年1月于笔者所在医院接受治疗的114例复治涂阳的肺结核患者,按照随机数字表法分为两组,各57例。两组均给予3HRZE/6HRE常规治疗,在此基础上,对照组加用3个月阿米卡星,0.6 g/次,1次/d,肌注;观察组加用左氧氟沙星,0.2 g/次,3次/d,治疗9个月。观察两组临床疗效、痰菌转阴和空洞闭合情况、血清IFN-γ和OPN水平及不良反应情况。结果:治疗后,观察组总有效率为91.2%,显著高于对照组的77.2%,差异有统计学意义(P<0.05);治疗后,观察组痰菌转阴率为89.5%,高于对照组的73.7%,差异有统计学意义(P<0.05);观察组空洞闭合率为73.7%,高于对照组的54.4%,差异有统计学意义(P<0.05);治疗后,两组血清IFN-γ和OPN水平均较治疗前下降,且观察组均显著低于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率为23.6%,低于对照组的28.1%,但差异无统计学意义(P>0.05)。结论:左氧氟沙星联合常规抗结核治疗方案用于复治肺结核患者中的临床效果良好,可调节机体细胞免疫,降低血清IFN-γ和OPN水平。
Objective:To explore the clinical efficacy of Levofloxacin-containing regimen in the treatment of retreated tuberculosis patients and its effect on serum interferon-γ(IFN-γ)and osteopontin(OPN).Method:A total of 114 cases of retreated smear-positive tuberculosis patients who were treated in our hospital from January 2018 to January 2019 were selected and divided into two groups according to random number table method,57 cases in each group.Both groups were given 3HRZE/6HRE conventional treatment.On this basis,the control group was given Amikacin for 3 months,0.6 g each time,1 times per day,intramuscular injection.The observation group was given Levofloxacin for 9 months,0.2 g each time,3 times per day.The clinical efficacy,the sputum bacteria turned negative and the cavity closed,the levels of serum IFN-γand OPN and adverse reactions of the two groups were observed.Result:After treatment,the total effective rate in the observation group was 91.2%,which was significantly higher than 77.2%of the control group,and the difference was statistically significant(P<0.05).After treatment,the sputum bacteria turned negative rate in the observation group was 89.5%,which was significantly higher than 73.7%of the control group,and the difference was statistically significant(P<0.05).The cavity closed rate in the observation group was 73.7%,which was significantly higher than 54.4%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum IFN-γand OPN of the two groups decreased compared with those before treatment,and the observation group were significant lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 23.6%,which was lower than 28.1%of the control group,but the difference was not statistically significant(P>0.05).Conclusion:Levofloxacin combined with conventional anti-tuberculosis treatment regimen has a good clinical efficacy in retreated tuberculosis pa
作者
罗勇强
林东子
孔祥裕
梅月志
李玉美
LUO Yongqiang;LIN Dongzi;KONG Xiangyu;MEI Yuezhi;LI Yumei(The Sixth People’s Hospital of Dongguan City,Dongguan 523008,China;不详)
出处
《中外医学研究》
2020年第23期7-10,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
