摘要
目的研究胃癌根治术对患者疗效、免疫炎症及趋化因子受体(CXCR)4,7水平的影响。方法回顾性分析2018年2月至2019年2月接受腹腔镜胃癌根治术治疗患者60例为研究组;另取2017年1月至2018年1月院接受开腹胃癌根治术治疗患者为对照组。比较2组临床疗效,手术前后各项炎性因子、免疫功能指标水平以及趋化因子受体-4(CXCR4)、趋化因子受体-7(CXCR7)阳性率。结果研究组手术时间长于对照组,而术中失血量、术后肛门排气时间、住院时间均低于对照组(P<0.05)。术后3 d研究组血清IL-6、TNF-α、hs-CRP水平均低于对照组(P<0.05)。术后3 d研究组CD4^+、CD4^+/CD8^+水平高于对照组,而CD8^+水平低于对照组(P<0.05)。术后3 d研究组CXCR4、CXCR7阳性率低于对照组(P<0.05)。结论腹腔镜胃癌根治术用于胃癌患者中的疗效显著,且有效改善患者的免疫炎症状态,降低CXCR4、CXCR7阳性率,值得临床推广应用。
Objective To investigate the therapeutic effects of radical gastrectomy on gastric cancer,and its effects on the levels of immune inflammation factors and CXCR 4,7 of patients.Methods A total of 60 patients with gastric cancer who underwent laparoscopic radical gastrectomy in our hospita l from February 2018 to February 2019 were enrolled as research group,at the same time,the patients who underwent open abdomen radical gastrectomy in our hospital from January 2017 to January 2018 were enrolled as control group.The clinical curative effects,and the changes of the levels of inflammatory cytokines and immune function indexes before and after surgery,and positive rates of CXCR4 and CXCR7 were observed and compared between the two groups.Results The operative time in research group was significantly longer than that in control group,however,the intraoperative blood loss,postoperative anal exhaust time and hospitalization time were significantly lower than those in control group(P<0.05).The serum levels of IL-6,TNF-αand hs-CRP in the 3d group in research group were significantly lower than those in control group(P<0.05).At 3 days after operation the levels of CD4^+,CD4^+/CD8^+in research group were significantly higher than those in control group,while CD8^+levels were significantly lower than those in control group(P<0.05).Moreover the positive rates of CXCR4 and CXCR7 at 3 days after operation in research group were significantly lower than those in control group(all P<0.05).Conclusion The laparoscopic radical gastrectomy in treatment of gastric cancer has significant therapeutic effects,moreover,which can effectively improve the immunoinflammatory status of patients,and reduce the positive rate of CXCR4 and CXCR7,therefor,it is worthy of clinical application and promotion.
作者
赵伟
唐思锋
王锋
王德友
ZHAO Wei;TANG Sifeng;WANG Feng(Department of Gastrointestinal Surgery,Jinan Municipal People’s Hospital,Shandong,Jinan 271199,China)
出处
《河北医药》
CAS
2020年第17期2637-2639,2643,共4页
Hebei Medical Journal
关键词
胃癌根治术
免疫功能
炎性反应
趋化因子受体
治疗结果
radical gastrectomy
immune function
inflammatory reaction
chemokine receptors
curative effects
