摘要
目的观察右美托咪啶联合利培酮治疗急性颅脑损伤术后患者躁动的临床疗效。方法选取2016年11月~2018年10月阳新县人民医院收治的64例急性颅脑损伤术后躁动患者为研究对象,按随机数字表法分为对照组和观察组,各32例。对照组使用奥氮平治疗,观察组使用右美托咪啶和利培酮治疗,比较两组患者治疗后效果(心率、呼吸频率、平均动脉压水平及治疗后效果)。结果两组患者治疗期间的呼吸频率及平均动脉压比较差异无统计学意义(P>0.05),而观察组心率低于对照组,差异有统计学意义(P<0.05)。经治疗后,观察组总有效率为87.5%,高于对照组总有效率为65.6%,差异有统计学意义(P<0.05)。结论对于急性颅脑损伤术后出现躁动表现的精神障碍患者,右美托咪啶联合利培酮具有显著疗效。
Objective To observe the clinical efficacy of dexmedetomidine combined with risperidone in patients with restlessness after acute craniocerebral injury surgery.Methods From November 2016 to October 2018,64 patients with restlessness after acute craniocerebral injury surgery admitted to Yangxin People's Hospital were selected as the research object and divided into the control group(n=32)and the observation group(n=32)according to random number table method.The control group was treated with olanzapine,while the observation group was treated with dexmedetomidine and risperidone.The post-treatment efficacies of the two groups were compared(the heart rate,respiratory frequency,mean arterial pressure level and post-treatment efficacies of the two groups during the treatment period were compared).Results There was no significant difference in respiratory frequency and mean arterial pressure between the two groups during treatment(P>0.05),while the heart rate in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).After treatment,the total efficacy rate of the observation group was 87.5%,which was higher than 65.6%of the control group,and the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine combined with risperidone has a significant application efficacy in patients with mental disorders with restlessness after acute craniocerebral injury surgery.
作者
孙桥梁
沈文娟
SUN Qiaoliang;SHEN Wenjuan(Department of Critical Care Medicine,Yangxin People's Hospital of Hubei Province,Hubei,Yangxin 435200,China)
出处
《中国医药科学》
2020年第15期91-93,96,共4页
China Medicine And Pharmacy
关键词
右美托咪啶
利培酮
颅脑损伤
躁动
Dexmedetomidine
Risperidone
Craniocerebral injury
Restlessness
