摘要
目的评估应用明胶海绵微粒TACE(GSM-TACE)联合伊马替尼治疗进展期胃肠道间质瘤(GIST)肝转移的临床疗效及安全性方法2013年1月—2019年1月收治9例不能外科手术的胃肠道间质瘤肝转移患者,规律服用伊马替尼治疗进展后,选用GSMs-TACE联合伊马替尼治疗,对患者的临床资料,CT随访结果,介入治疗的并发症及预后等情况进行总结和分析。术后采用改良实体瘤评价标准(mRECIST)标准评估疗效,术后每月随访1次。结果9例GIST肝转移均为接受伊马替尼治疗6~30个月进展的患者,且无外科根治性手术指征;9例患者共接受17次GSM-TACE治疗;根据mRECIST评价标准,完全缓解(CR)4例,部分缓解(PR)5例;中位生存时间(24±4.4)个月;无肝脓肿形成,未发生与介入相关的严重并发症。结论GMS-TACE联合伊马替尼治疗胃肠道间质瘤肝转移是一种安全的、有效的治疗方法。
Objective To evaluate the clinical efficacy and safety of transcatheter arterial chemoembolization with gelatin sponge microparticles(GSMs-TACE)combined with imatinib in treating liver metastases from advanced gastrointestinal stromal tumors(GIST).Methods From January 2013 to January2019,a total of 9 patients with liver metastases from inoperable GIST,whose metastatic lesions failed to response to regular oral imatinib treatment,were treated with GSMs-TACE in combination with imatinib.The clinical data,CT follow-up results,complications of interventional therapy and prognosis were summarized and analyzed.The curative effect was evaluated by modified response evaluation criteria in solid tumors(mRECIST).The patients were followed up once a month.Results All 9 patients with liver metastases from inoperable GIST had been treated with imatinib for 6-30 months but the lesions were still progressing,and the patients had no indications of radical surgery.Then,the patients had to receive GSMs-TACE treatment.A total of 17 GSMs-TACE procedures were carried out in 9 patients.According to mRECIST,complete response(CR)was achieved in 4 patients and partial remission(PR)in 5 patients.The median survival time was(24±4.4)months.No serious complications such as hepatic abscess formation or intervention-related adverse reactions occurred.Conclusion For liver metastases from GIST,GMSs-TACE combined with imatinib is a safe and effective treatment.
作者
敖劲
杨孔武
穆茂媛
石明涛
利峰
蔡争
杨明镇
石荣书
AO Jin;YANG Kongwu;MU Maoyuan;SHI Mingtao;LI Feng;CAI Zheng;YANG Mingzhen;SHI Rongshu(Department of Interventional Radiology,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province 563003,China)
出处
《介入放射学杂志》
CSCD
北大核心
2020年第8期820-823,共4页
Journal of Interventional Radiology
关键词
肝动脉灌注化疗栓塞
胃肠间质瘤
肝转移瘤
伊马替尼
transcatheter arterial chemoembolization
gastrointestinal stromal tumor
liver metastasis
imatinib
