摘要
目的探讨凡士林纱块联合维生素B12合剂溶液在Ⅱ度放射性皮肤损伤换药中的应用效果。方法选取2019年1~11月我院收治的因调强放射治疗而引发Ⅱ度放射性皮肤损伤的90例患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各45例。对照组采用浸透维生素B12合剂溶液的无菌纱块湿敷,观察组在对照组的基础上加用凡士林纱块敷贴。比较两组患者治疗前后的临床疗效、疼痛感评分及表皮细胞因子[血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β1)、碱性成纤维细胞生长因子(bFGF)]水平。结果观察组患者治疗后的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗15、30 min后,观察组患者的疼痛数字分级法(NRS)评分低于对照组,差异有统计学意义(P<0.05)。治疗3 d后,观察组患者的VEGF、TGF-β1、bFGF水平均高于对照组,差异有统计学意义(P<0.05)。结论凡士林纱块联合维生素B12合剂溶液在Ⅱ度放射性皮肤损伤换药中的应用效果良好,可有效缓解患者的疼痛感,促进皮肤组织恢复,调节表皮细胞因子的表达。
Objective To explore the application effect of Petrolatum gauze block combined with Vitamin B12 Mixture Solution in dressing change for second-degree radiation skin injury.Methods From January to November 2019,90 patients with second-degree radiation skin injury caused by intensity-modulated radiotherapy were selected as subjects and divided into control group and observation group by random number table method,with 45 cases in each group.The control group used sterile gauze block soaked with Vitamin B12 Mixture Solution for wet compress,and the observation group was added with Petrolatum gauze block on the basis of the control group.The clinical efficacy,pain scores,and epidermal cytokine(vascular endothelial growth factor[VEGF],transforming growth factor-β[TGF-β1],basic fibroblast growth factor[bFGF])levels before and after treatment were compared between the two groups of patients after treatment]expression.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment for 15 and 30 minutes,the numerical grading method(NRS)pain score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment for 3 days,the levels of VEGF,TGF-β1 and bFGF in the observation group were all higher than those in the control group,with statistically significant differences(P<0.05).Conclusion Petrolatum gauze block combined with Vitamin B12 Mixture Solution has a good application effect in the second-degree radiation skin injury dressing change,which can effectively relieve the pain of patients,promote skin tissue recovery,and regulate the expression of epidermal cytokines.
作者
刘晓云
温盛瑛
曾莺婷
LIU Xiao-yun;WEN Sheng-ying;ZENG Ying-ting(The Third Department of Radiotherapy,Ganzhou Cancer Hospital,Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
2020年第24期62-65,共4页
China Modern Medicine
基金
江西省赣州市指导性科技计划项目(GZ2018ZSF 359)。
关键词
凡士林纱块
Ⅱ度放射性皮肤损伤
外敷药物
疼痛感
表皮细胞因子
Petrolatum gauze block
Second-degree radiation skin injury
External medicine
Pain
Epidermal cytokines
