摘要
目的探讨四逆汤对急性心肌梗死(AMI)缺血再灌注损伤患者心肌损伤标记物水平的影响.方法选取2018年4月—2019年11月接受治疗的109例AMI缺血再灌注损伤患者,依据盲抽法分为对照组(54例)与观察组(55例).2组均予以常规治疗,在此基础上,对照组予以尿激酶溶栓治疗,观察组在对照组基础上加用四逆汤治疗,比较2组临床疗效、心肌损伤标志物水平及不良反应发生率.结果观察组总有效率94.55%高于对照组总有效率79.63%,差异有统计学意义(P<0.05);治疗后,2组CK-MB、cTnI、NT-proBNP水平均较治疗前低,且观察组较对照组低,差异有统计学意义(P<0.05);与对照组不良反应发生率(11.11%)相比,观察组(3.64%)略低,但差异无统计学意义(P>0.05).结论AMI缺血再灌注损伤患者采用四逆汤治疗效果显著,可有效改善患者心肌损伤标志物水平,且安全性高.
Objective To investigate the effect of Sini decoction on markers of myocardial injury in patients with acute myocardial infarction(AMI)ischemia-reperfusion injury.Methods 109 patients with AMI ischemia-reperfusion injury who were treated in our hospital from April 2018 to November 2019 were divided into control group(n=54)and observation group(n=55)according to blind extraction.The two groups were routinely treated.On this basis,the control group was treated with urokinase thrombolysis,and the observation group was treated with Sini decoction on the basis of the control group.Comparison of clinical effect,myocardial injury markers and incidence of adverse reactions between the two groups was carried out.Results The total effective rate of the control group was 79.63%,the total effective rate of the observation group was 94.55%,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the average water of CK-MB,cTnl and NT-proBNP in the two groups was lower than that before treatment,those of the observation group was lower than that of the control group,and the difference was statistically significant(P V 0.05).The incidence of adverse reactions of the control group was 11.11%,which was slightly higher than 3.64%of the observation grou,but the difference was not statistically significant(P>0.05).Conclusion Sini decoction is effective in treating patients with AMI ischemia-reperfusion injury,can effectively improve the level of myocardial injury markers and has high safety.
作者
王德祥
WANG Dexiang(Department of Cardiology,Sheyang County Hospital of Traditional Chinese Medicine,Jiangsu Province,Yancheng 224300,China)
出处
《光明中医》
2020年第16期2435-2437,共3页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
胸痹
急性心肌梗死
缺血再灌注损伤
四逆汤
心肌损伤标志物
中医药疗法
thoracic obstruction
acute myocardial infarction
ischemia-reperfusion injury
Sini decoction
markers of myocardial injury
therapy of TCM
