摘要
目的利用扩散张量成像(DTI)探究不同级别创伤性脑损伤(TBI)患者白质结构改变及其与认知功能的相关性。方法收集TBI患者28例及健康志愿者28例,基于DTI获得各向异性分数(FA)、平均弥散率(MD)、轴向扩散张量(AD)、垂直扩散张量(RD)等参量,利用纤维束空间统计(TBSS)及感兴趣区域分析进行组间比较,同时分析各参量与简易智能精神状态量表(MMSE)的相关性。结果相较健康志愿者,轻度TBI胼胝体膝部、双侧下额枕束、右侧下纵束及左侧钩束FA降低,MD、RD、AD增加;而中度、重度患者AD在胼胝体区域降低。感兴趣区域内FA值与MMSE呈正相关,MD、AD、RD值则与MMSE呈负相关。结论 DTI可客观、量化评价不同级别TBI脑损伤程度及分布特点,且白质损伤程度与康复期认知功能相关。
Objective To evaluate white matter alterations and relation with cognitive functions of patients with traumatic brain injury(TBI)by diffusion tensor imaging(DTI).Methods Twenty-eightTBIpatients and 28 healthy controls were enrolled.DTI-metrics,i.e.fractional anisotropy(FA),mean diffusivity(MD),axial diffusivity(AD),and radial diffusivity(RD),were calculated.Differences between patients and controls were compared by tract-based spatial statistics(TBSS).Relationships of DTI-metrics with mini-mental state examination(MMSE)were analyzed by Pearson correlations.Results Compared with controls,mild TBIpatients showed decreased FA and increased MD,AD,and RD,while moderate and severe TBI demonstrated decreased AD in corpus callosum.Furthermore,positive correlation could be found between MMSE and FA,while negative correlations between MMSE and MD,AD,RD.Conclusion DTI can objectively and quantitatively evaluate degrees and distribution of white matter alterations associated with TBI of different grades.The degree of white matter injury is related to convalescence cognitive dysfunctions.
作者
陈苗苗
李华
张玉利
金超
杨健
李贤军
CHEN Miao-miao;LI Hua;ZHANG Yu-li(Department of Radiology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province,China)
出处
《中国CT和MRI杂志》
2020年第10期1-3,7,共4页
Chinese Journal of CT and MRI
基金
国家自然科学基金面上项目(编号:81901823、81971581、81901516)
国家重点研发计划(编号:2016YFC0100300)
中国博士后科学基金(编号:2019M653659)
陕西省自然科学基础研究计划(编号:2019JQ-198)。
