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高效抗逆转录病毒治疗对HIV感染者心脏功能的影响 被引量:5

Effect of highly active anti-retroviral therapy on cardiac function in HIV-infected patients
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摘要 目的探讨高效抗逆转录病毒治疗(HAART)对HIV感染者心脏功能的影响。方法选择长期规律进行HAART法治疗的35例HIV感染者作为HAART组,拒绝HAART法治疗的21例HIV感染者作为未治疗组,另选择32例健康志愿者作为健康对照组,所有研究对象均进行心脏彩色多普勒超声检查。比较3组研究对象的心脏功能,分析HAART对HIV感染者心脏功能的影响。结果3组研究对象的舒张早期最大血流速度/舒张晚期最大血流速度(E/A)比值、二尖瓣环舒张早期峰值速度(Ea)、E/Ea比值、左室等容舒张时间、射血分数、左室缩短率的差异均无统计学意义(P>0.05);而健康对照组、未治疗组、HAART组的E峰减速时间依次缩短,且HAART组的E峰减速时间与服药时长呈负相关,未治疗组患者的E峰减速时间与病程亦呈负相关(均P<0.05)。结论HIV感染者的心脏功能存在亚临床变化。HAART及HIV病毒本身均可影响患者的心脏功能,治疗时长或病程越长,HIV患者心功能越差。 Objective To investigate the effect of highly active anti-retroviral therapy(HAART)on the cardiac function in HIV-infected patients.Methods Thirty-five HIV-infected patients who were treated with long-term regular HAART were selected as the HAART group,21 HIV-infected patients who refused HAART were selected as untreated group,and another 32 healthy volunteers as healthy control group.All subjects underwent cardiac color Doppler ultrasonography.Subjects'cardiac function was compared among the three groups,and the effect of HAART on the cardiac function of HIV-infected patients was analyzed.Results There was no statistically significant difference among the subjects in the three groups in ratio of peak early and late diastolic flow velocities(E/A),peak early mitral annular diastolic velocity(Ea),E/Ea ratio,left ventricular isovolumic relaxation time,ejection fraction,or left ventricular shortening rate(P>0.05);however,the E-peak deceleration time of the healthy control group,the untreated group,and the HAART group decreased in turn,and E-peak deceleration time negatively correlated with medication duration in the HAART group,and also negatively correlated with course of disease in the untreated group(all P<0.05).Conclusion Subclinical alteration in cardiac function is observed in HIV-infected patients.Both HAART and HIV virus itself can affect patients'cardiac function,and in HIV patients,the longer the treatment period/course of disease,the worse the cardiac function.
作者 韦吉伟 赵红洋 胡庆 WEI Ji-wei;ZHAO Hong-yang;HU Qing(Outpatient Department,the Second Nanning People's Hospital,Nanning 530031,China;HIV Clinic,the Sixth People's Hospital of Nanning,Nanning 530003,China)
出处 《广西医学》 CAS 2020年第15期1943-1945,共3页 Guangxi Medical Journal
基金 广西医药卫生科研课题(Z20180548)。
关键词 HIV感染者 高效抗逆转录病毒治疗 心脏功能 HIV-infected patients Highly active anti-retroviral therapy Cardiac function
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