摘要
目的分析血清中血红蛋白(Hb)、白蛋白(ALB)水平与慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者预后的相关性,旨在为临床AECOPD患者病情评估及预后评价提供新的思路及方向。方法回顾性分析2018年3月至2019年10月收治的AECOPD患者106例临床资料。根据患者预后将其分为存活组和死亡组,存活组87例,死亡组19例。调查两组患者一般资料、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]、血气指标[血氧分压(PaO2),动脉二氧化碳分压(PaCO2)]、血清指标(Hb、ALB)。采用Spearman相关分析Hb、ALB与AECOPD患者预后的相关性。结果存活组FEV1/FVC、PaO2高于死亡组,PaCO2低于死亡组,差异有统计学意义(P<0.01);存活组Hb低于死亡组[(146.98±15.64)g/L vs(187.95±18.64)g/L],ALB高于死亡组[(39.65±5.21)g/L vs(31.25±4.01)g/L],差异有统计学意义(P<0.01);Spearman相关分析发现,Hb水平与AECOPD患者预后呈负相关关系(r=-0.700,P<0.05);ALB水平与AECOPD患者预后呈正相关关系(r=0.543,P<0.05)。结论Hb、ALB水平与AECOPD患者预后密切相关,Hb水平越高,ALB水平越低,患者预后越差,其可有效反映患者病情严重程度。
Objective To analyze the associations of serum hemoglobin(Hb)and albumin(ALB)levels with the prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)to provide new ideas in prognostic evaluation of patients with AECOPD.Methods The clinical data of 106 patients with AECOPD from March 2018 to October 2019 were analyzed retrospectively.The patients were divided into survival group(n=87)and death group(n=19)according to the prognosis.The general situations questionnaire was designed to record the general data(gender,age,course of disease),pulmonary function indexes[forced expiratory volume in first second(FEV1),forced vital capacity(FVC),FEV1/FVC],blood gas indexes[partial pressure of blood oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)]and serum indexes(Hb,ALB)in two groups.Spearman method was used to analyze the associations of Hb and ALB with the prognosis of patients with AECOPD.Results FEV1/FVC and PaO2 in survival group were higher than those in death group,and PaCO2 was lower than that in death group(P<0.01);HB level in survival group was lower than that in death group[(146.98±15.64)g/L vs(187.95±18.64)g/L,P<0.01],and ALB level in survival group was higher than that in death group[(39.65±5.21)g/L vs(31.25±4.01)g/L,P<0.01].Spearman correlation analysis showed that Hb level was negatively correlated with the prognosis of AECOPD patients(r=-0.700,P<0.05),and ALB level was positively correlated with the prognosis of AECOPD patients(r=0.543,P<0.05).Conclusion The levels of Hb and ALB are closely related to the prognosis of patients with AECOPD and can effectively reflect the severity of the disease.Higher Hb level and lower ALB level are correlated with the worse prognosis of patients.
作者
张艳
王春梅
ZHANG Yan;WANG Chun-mei(Department of Respiratory Medicine,Zhangye People's Hospital of Hexi University,Zhangye,Gansu 734000,China)
出处
《中国临床研究》
CAS
2020年第8期1094-1096,1100,共4页
Chinese Journal of Clinical Research
关键词
慢性阻塞性肺疾病
急性加重期
血红蛋白
白蛋白
预后
Chronic obstructive pulmonary disease
Acute exacerbation
Hemoglobin
Albumin
Prognosis
