摘要
脊髓损伤是一种毁灭性的神经系统疾病,是年轻人的主要致残致死原因。但目前没有治疗脊髓损伤确切方法。氢气是密度最小且无色无味的气体,具有可燃性和一定还原性,可选择性清楚氧自由基。目前氢气成为治疗疾病的热点:包括多种器官缺血再灌注损伤、神经退行性疾病、骨关节疾病、呼吸系统疾病,可以对脊髓损伤模型中炎症损伤、自噬形成机制及氢气可能的神经保护病理生理机制进行进一步的探讨,提高脊髓损伤后神经功能恢复。
Spinal cord injury is a devastating nervous system disease,which is the main cause of disability and death in young people.But there is no definite method to treat spinal cord injury.Hydrogen is the least dense,colorless and tasteless gas,which has flammability and certain reducibility,and can selectively clear oxygen free radicals.At present,hydrogen has become a hot spot in the treatment of diseases,including multiple organ ischemia-reperfusion injury,neurodegenerative diseases,bone and joint diseases,respiratory system diseases.It can further explore the mechanism of inflammation injury,autophagy and the possible neuroprotective pathophysiological mechanism of hydrogen in the spinal cord injury model,so as to improve the recovery of nerve function after spinal cord injury.
作者
张钦
杨晓慧
王翠
庾红林
解国辉
Zhang Qin;Yang Xiaohui;Wang Cui;Yu Honglin;Xie Guohui(Department of Spinal Surgery,Yuncheng Central Hospital Affiliated to Shanxi Medical University,Yuncheng,Shanxi 044000,China;Department of Imaging,Yuncheng Central Hospital Affiliated to Shanxi Medical University,Yuncheng,Shanxi 044000,China;Department of Scientific Research,Yuncheng Central Hospital Affiliated to Shanxi Medical University,Yuncheng,Shanxi 044000,China)
出处
《中国基层医药》
CAS
2020年第17期2173-2176,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脊髓损伤
氢气
自由基
自噬
综述
Spinal cord injuries
Hydrogen
Free radicals
Autophagy
Review
