摘要
目的分析白三烯受体拮抗剂在缓解期老年支气管哮喘治疗中的应用效果。方法于商丘市第一人民医院2018年1月—2019年12月收治的缓解期支气管哮喘患者患者中选取138例,随机分为研究组70例和对照组68例,对照组接受常规治疗,研究组在此基础上加用白三烯受体拮抗剂(孟鲁司特钠)治疗,比较两组治疗后疗效、肺功能及炎性因子水平。结果研究组治疗后总有效率为92.86%,与对照组的79.41%比较,差异有统计学意义(P<0.05)。研究组治疗后FEV1为(2.86±0.43)L、FVC为(5.47±0.35)L及FEV1/FVC为(77.64±11.32)%,与对照组各指标比较差异明显(P<0.05)。研究组治疗后TNF-α为(3.05±0.62)pg/mL、IL-6为(1.57±0.34)pg/mL、IL-8为(2.78±0.35)ng/mL,与对照组的(4.27±0.81)pg/mL、(2.21±0.39)pg/mL和(4.33±0.52)ng/mL比较,差异有统计学意义(P<0.05)。两组不良反应无明差异(P>0.05)。结论缓解期老年支气管哮喘治疗中,应用白三烯受体拮抗剂可有效减轻患者炎性反应,改善患者肺功能,从而增强患者临床治疗效果,可推广应用。
Objective to analyze the effect of leukotriene receptor antagonist in the treatment of bronchial asthma in the remission stage of the elderly.Methods in our hospital from January 2018 to December 2019 were remission in patients with bronchial asthma to select 138 cases,70 cases were randomly divided into research group and the control group of 68 cases in control group accepted routine treatment,the team on the basis of the used leukotriene receptor antagonists(meng LuSi sodium)treatment,compared two groups of curative effect after treatment,pulmonary function and inflammatory factor levels.Results the total effective rate in the study group was 92.86%,which was statistically significant compared with 79.41%in the control group(P<0.05).After treatment,FEV1 was(2.86±0.43)L,FVC was(5.47±0.35)L and FEV1/FVC was(77.64±11.32)%in the study group,which were significantly different from the control group(P<0.05).After treatment,TNF-,il-6 and il-8 in the study group were(3.05±0.62)pg/mL,(1.57±0.34)pg/mL and(2.78±0.35)ng/mL,respectively.The differences were statistically significant(P<0.05)when compared with the control group(4.27±0.81)pg/mL,(2.21±0.39)pg/mL and(4.33±0.52)ng/mL.There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion the application of leukotriene receptor antagonist in the treatment of aged bronchial asthma in remission stage can effectively reduce the inflammatory response of patients,improve the lung function of patients,so as to enhance the clinical therapeutic effect of patients.
作者
杨美菊
YANG Mei-ju(Shangqiu First Peoples Hospital,Shangqiu Henan 476100,China)
出处
《医药论坛杂志》
2020年第8期38-40,共3页
Journal of Medical Forum
关键词
白三烯受体
拮抗剂
缓解期
老年支气管哮喘
治疗效果
leukotriene receptor
Antagonists
Remission
Bronchial asthma in the elderly
Treatment effect
