摘要
目的探讨急性淋巴细胞白血病(ALL)患儿血清胸苷激酶1(TK1)及E-钙黏蛋白(E-cadherin)表达水平及意义。方法选取本院2017年1月至2019年3月诊治的ALL患儿172例(观察组,n=175),同时选取健康儿童30例(对照组,n=30),检测血清TK1及E-cadherin水平,分析血清TK1及E-cadherin水平相关性及其与临床特征的关系。结果观察组血清TK1水平高于对照组(P<0.05),E-cadherin水平低于对照组(P<0.05);不同年龄、不同性别、不同ALL类型血清TK1及E-cadherin水平无显著差异(P>0.05),不同WBC水平及是否发生髓外浸润ALL的血清TK1及E-cadherin水平存在显著差异(P<0.05),相关分析结果显示,ALL患儿TK1与E-cadherin水平呈现负相关(r=-0.401,P<0.05),TK1水平与WBC呈现正相关(r=0.421,P<0.05),E-cadherin水平与WCB呈现负相关(r=-0.505,P<0.05)。结论ALL患儿血清TK1高表达而E-cadherin低表达,并且与部分临床特征相关,对其检测有助于白细胞负荷和髓外浸润的评估。
Objective To investigate expression and significance of serum TK1 and E-cadher in children with acute lymphoblastic leukemia(ALL).Methods 172 children with ALL were selected in our hospital from Jan 2017 to Mar 2019(the observation group,n=175)and 30 healthy children were selected(the control group,n=30).Serum level of TK1 and E-cadherin were measured,and the correlation between TK1 or E-cadherin with clinical characteristics was analyzed.Results The levels of TK1 and E-cadherin in serum were higher in the observation group than those in the control group(P<0.05),but no significant difference in different age,gender and ALL types(P>0.05).There are significant differences in serum TK1 and E-cadherin levels between different WBC levels and whether extramedullary infiltrating ALL occurs(P<0.05).Correlation analysis results show that TK1 and E-cadherin levels in ALL children are negatively correlated(r=-0.401,P<0.05).TK1 level was positively correlated with WBC count(r=0.421,P<0.05),E-cadherin level was negatively correlated with WCB count(r=-0.505,P<0.05).Conclusions The serum TK1 expression in children with ALL is high and E-cadherin expression is low,and it is related to some clinical features.The detection of TK1 and E-cadherin is helpful for the assessment of white blood cell load and extramedullary infiltration.
作者
邢东文
张余转
林坚
林鲁飞
XING Dongwen;ZHANG Yuzhuan;LIN Jian;LIN Lufei(Department of Pediatrics,Haikou Third People's Hospital,Haikou,Hainan,China,571199;Department of Pediatrics,Haikou Fourth People's Hospital,Haikou,Hainan,China,571199)
出处
《分子诊断与治疗杂志》
2020年第8期1010-1013,共4页
Journal of Molecular Diagnostics and Therapy
基金
海南省自然科学基金项目(2018-8154283)。
