摘要
目的探讨伊伐布雷定联合益心舒片对稳定型心绞痛患者血管内皮细胞功能的影响。方法选取2017年2月—2020年2月本院收治的90例稳定型心绞痛患者,按照随机数字表法分为研究组和对照组,各45例。对照组患者采用盐酸伊伐布雷定片治疗,研究组患者采用盐酸伊伐布雷定片联合益心舒片治疗。比较2组患者治疗前后心绞痛发作情况及血管内皮细胞功能相关指标变化。结果治疗12周后,2组患者心绞痛发作次数和持续时间均较治疗前明显降低,且研究组显著低于对照组(P<0.05)。2组患者西雅图心绞痛量表(SAQ)评分均较治疗前明显降低,且研究组显著低于对照组(P<0.05)。2组患者一氧化氮(NO)和肱动脉血流介导的血管内皮舒张功能(FMD)水平均较治疗前明显升高,且研究组显著高于对照组(P<0.05);内皮素(ET)-1水平较治疗前明显降低;且研究组显著低于对照组(P<0.05)。结论采用伊伐布雷定联合益心舒片治疗稳定型心绞痛患者可显著降低心绞痛发作次数和持续时间,提高生活质量及机体功能状态,恢复血管内皮细胞功能。
Objective To investigate the effect of ivabradine combined with Yixinshu tablet on vascular endothelial cell function in patients with stable angina pectoris.Methods From February 2017 to February 2020,ninety patients with stable angina pectoris in our hospital were divided into study group and control group according to the method of random number table,with 45 cases in each group.The control group was treated with ivabradine hydrochloride tablets,and the study group was treated with ivabradine hydrochloride tablets combined with Yixinshu tablets.The number and duration of angina pectoris,the changes of vascular endothelial cell function were compared before and after treatment.Results After 12 weeks of treatment,the number and duration of angina pectoris in the two groups were significantly lower than those before treatment,and the study group was significantly lower than that in the control group(P<0.05).The scores of Seattle angina scale(SAQ)in the two groups were significantly lower than those before treatment,and the study group was significantly lower than that in the control group(P<0.05).The levels of nitric oxide(NO)and flow mediated dilation(FMD)in the two groups were significantly higher than those before treatment,and the study group was significantly higher than that in the control group(P<0.05).The levels of endothelin(ET-1)in the two groups were significantly lower than those before treatment,and the study group was significantly lower than that in the control group(P<0.05).Conclusion The treatment of patients with stable angina pecton’s with ivabradine combined with Yixinshu tablet could significantly reduce the number and duration of angina pectoris,improve the quality of life and the state of body function,and restore the function of vascular endothelial cells.
作者
朱改针
谢国旗
卫世强
ZHU Gaizhen;XIE Guoqi;WEI Shiqiang(Department of Cardiology,the 83rd army hospital,Xinxiang 453000,China)
出处
《中西医结合研究》
2020年第4期222-224,共3页
Research of Integrated Traditional Chinese and Western Medicine
关键词
益心舒片
伊伐布雷定
稳定型心绞痛
血管内皮细胞功能
Yixinshu tablet
ivabradine
stable angina pectoris
vascular endothelial cells function
