摘要
目的:探讨伏立康唑引起神经系统药品不良反应(ADRs)的特征,为临床合理用药提供参考。方法:对一例伏立康唑引起癫■发作及精神障碍病例的临床表现、高危因素进行分析,并结合相关文献分析其发生机制及防治措施。结果:癫■发作是伏立康唑少见的神经系统ADRs,本例患者伏立康唑血药浓度过高是引发神经系统ADRs的主要原因。结论:临床使用伏立康唑应进行血药浓度监测,实行个体化用药,避免因血药浓度过高引起神经系统ADRs。
Objective:To explore the characteristics of voriconazole-induced adverse drug reactions(ADRs)in the nervous system,so as to provide reference for rational drug use clinically.Methods:Clinical manifestations and high risk factors in a case of voriconazole-induced epilepsy seizure and mental disorders were analyzed,and pathogenic mechanism as well as prevention and treatment measures were also analyzed in combination with relevant literature.Results:Epilepsy seizure was rarely seen in neurological ADRs induced by voriconazole.High blood concentration of voriconazole in the patient was the main cause of nervous system ADRs.Conclusion:Blood concentration monitoring of voriconazole was mandatory clinically,and individualized medication should be implemented,so that ADRs in the nervous system could be avoided due to high blood concentration of voriconazole.
作者
刘香芳
蔡婕
滕文兵
倪穗琴
LIU Xiangfang;CAI Jie;TENG Wenbing;NI Suiqin(Department of Clinical Pharmacy,Guangzhou First People’s Hospital,Guangzhou 510180,China)
出处
《药学服务与研究》
CAS
2020年第4期288-290,295,共4页
Pharmaceutical Care and Research
基金
广东省医学科学技术研究基金(A2019572)
广东省医院药学研究基金(2018LR04)。
关键词
伏立康唑
癫■
精神障碍
药物副反应报告系统
voriconazole
epilepsy
mental disorder
adverse drug reaction reporting system
