摘要
目的观察无创通气治疗慢性阻塞性肺疾病(COPD)合并睡眠呼吸暂停低通气综合征(SAHS)患者的临床疗效。方法40例慢性阻塞性肺疾病合并睡眠呼吸暂停低通气综合征患者,根据医院接诊时间先后分为观察组与对照组,各20例。对照组采用异丙托溴铵气雾剂联合茶碱缓释片治疗,观察组在对照组基础上采取无创通气治疗。比较两组患者治疗前后肺功能指标,血气指标、肺动脉压指标。结果治疗前,两组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC比较,差异无统计学意义(P>0.05);治疗后,观察组患者FVC、FEV1、FEV1/FVC优于对照组,差异有统计学意义(P<0.05)。观察组患者动脉血氧饱和度(91.38±9.12)%、动脉血氧分压(81.35±4.62)mm Hg(1 mm Hg=0.133 kPa)均高于对照组的(84.23±8.16)%、(76.47±5.31)mm Hg,肺动脉收缩压(30.23±2.51)mm Hg、二氧化碳分压(39.74±3.56)mm Hg均低于对照组的(38.35±3.26)、(42.36±3.03)mm Hg,差异有统计学意义(P<0.05)。结论无创通气治疗慢性阻塞性肺疾病合并睡眠呼吸暂停低通气综合征患者,可稳定患者心率、呼吸频率,改善患者肺功能,提升治疗效果,值得临床实践。
Objective To observe the clinical efficacy of noninvasive ventilation in patients with chronic obstructive pulmonary disease(COPD)and sleep apnea/hypopnea syndrome(SAHS).Methods A total of 40 patients with chronic obstructive pulmonary disease and sleep apnea/hypopnea syndrome were divided into observation group and control group according to the hospital reception time,with 20 cases in each group.The control group was treated by ipratropium bromide aerosol combined with theophylline sustained release tablets,and the observation group was treated by noninvasive ventilation on the basis of the control group.The pulmonary function indexes,blood gas indexes and pulmonary arterial pressure indexes before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and FEV1/FVC between the two groups(P>0.05).After treatment,FVC,FEV1 and FEV1/FVC of the observation group was better than those of the control group,and the difference was statistically significant(P<0.05).The arterial oxygen saturation(91.38±9.12)%,pulmonary artery systolic blood pressure(81.35±4.62)mm Hg(1 mm Hg=0.133 kPa)of the observation group were higher than those of the control group(84.23±8.16)%,(76.47±5.31)mm Hg,and pulmonary artery systolic pressure(30.23±2.51)mm Hg,partial pressure of carbon dioxide(39.74±3.56)mm Hg were lower than those of the control group(38.35±3.26),(42.36±3.03)mm Hg,and the difference was statistically significant(P<0.05).Conclusion Noninvasive ventilation can stabilize the heart rate and respiratory frequency of patients with chronic obstructive pulmonary disease and sleep apnea/hypopnea syndrome,improve the pulmonary function and the efficiency of treatment.It is worth clinical practice.
作者
蔡木泾
黄如坤
麦校敬
CAI Mu-jing;HUANG Ru-kun;MAI Xiao-jing(Shanwei People's Hospital,Shanwei 516600,China)
出处
《中国实用医药》
2020年第22期28-30,共3页
China Practical Medicine
关键词
睡眠呼吸暂停低通气综合征
慢性阻塞性肺疾病
无创通气
Sleep apnea/hypopnea syndrome
Chronic obstructive pulmonary disease
Noninvasive ventilation
