摘要
目的探讨三亚市158例耐多药结核病(MDR-TB)患者的危险因素,为MDR-TB的防治提供科学依据。方法对三亚市158例MDR-TB患者(病例组)和316例敏感性结核患者(对照组)的相关情况进行调查,应用单因素及多因素Logistic回归模型分析MDR-TB发生的危险因素。结果单因素及多因素Logistic回归分析显示,居住地(OR=2.308,95%CI:1.597~5.104)、既往抗结核治疗史(OR=16.218,95%CI:14.815~25.106)、结核空洞(OR=2.904,95%CI:2.116~7.915)、治疗过程中断(OR=5.706,95%CI:4.508~12.319)、抗结核药物不良反应(OR=3.382,95%CI:2.672~10.137)、不规律用药(OR=2.508,95%CI:1.813~5.646)及首次抗结核治疗效果(OR=3.513,95%CI:2.914~10.870)是MDR-TB发生的危险因素。结论三亚市MDR-TB发生的危险因素较多,需要进一步加强早期发现和规范诊疗,以减少MDR-TB的发生。
Objective To investigate the risk factors of 158 patients with multi-drug resistant tuberculosis(MDR-TB)in Sanya,and we provide scientific basis for the prevention and treatment of MDR-TB.Methods The correlation between 158 MDR-TB patients(case group)and 316 sensitive TB patients(control group)in Sanya was investigated by single-factor and multivariate logistic regression.Univariate and multivariate Logistic regression were used to analyze the risk factors of MDRTB.Results Univariate and multivariate Logistic regression analysis showed that residence(OR=2.308,95%CI:1.597-5.104),previous anti-tuberculosis treatment history(OR=16.218,95%CI:14.815-25.106),tuberculosis cavity(OR=2.904,95%CI:2.116-7.915),discontinuation of treatment(OR=5.706,95%CI:4.508-12.319),adverse reactions to antituberculosis drugs(OR=3.382,95%CI:2.672-10.137),irregular drug use(OR=2.508,95%CI:1.813-5.646)and first antituberculosis therapeutic effect(OR=3.513,95%CI:2.914-10.870)were risk factors for MDR-TB.Conclusion There are many risk factors for the occurrence of MDR-TB in Sanya,and early detection,standardized diagnosis and treatment need to be further strengthened to reduce the occurrence of MDR-TB.
作者
符婷
黄丽菊
杨进军
卓越
肖华
FU Ting;HUANG Lijiu;YANG Jinjun;ZHUO Yue;XIAO Hua(Sanya Central Hospital(The Third People's Hospital of Hainan Province),Sanya,Hainan 572000,China)
出处
《中国热带医学》
CAS
2020年第8期789-793,共5页
China Tropical Medicine
关键词
耐多药结核病
结核分枝杆菌
危险因素
Multidrug-resistant tuberculosis
Mycobacterium tuberculosis
risk factors
