摘要
炎症性肠病是一种由肠道菌群与肠道免疫系统相互作用导致的慢性炎性疾病,通常受多种因素影响,多呈慢性、复发性或进行性炎症的病理表现,主要表现为肠道免疫反应和正常肠道菌群的改变,主要包括溃疡性结肠炎和Crohn病两种形式。目前关于炎症性肠病的病因和发病机制尚未明确,治疗方面也依然存在很多难点。众所周知,人体的肠道菌群是一个巨大的微生物生态系统,主要包括优势菌群、条件致病菌及病原菌三种类型,与人体正常机能的发挥关系密切,而肠道是机体最大的免疫器官,肠黏膜免疫系统是机体抵御肠腔内病原微生物入侵的第一道防线,已被公认为机体最重要的屏障之一,这两者可以通过复杂的交互作用来维持肠道内环境的稳态。该文将围绕肠道菌群、肠道免疫与炎症性肠病的相关性来探讨炎症性肠病的治疗策略。
Inflammatory bowel disease(IBD) is a chronic inflammatory disease caused by the interaction of intestinal flora and the intestinal immune system.It is usually affected by a variety of factors,most of which are chronic,recurrent or progressive inflammation.The pathological manifestations are mainly manifested as intestinal immune response and normal intestinal flora changes,mainly including ulcerative colitis(UC) and Crohn’s disease(CD) two forms.At present,the etiology and pathogenesis of inflammatory bowel disease are not clear,and there are still many difficulties in treatment.As we all know,the intestinal flora of the human body is a huge microbial ecosystem,mainly including three types of dominant bacteria,conditional pathogens and pathogenic bacteria,which are closely related to the normal function of the human body,and the intestine is the body’s largest immune organ.The intestinal mucosal immune system is the body’s first line of defense against the invasion of pathogenic microorganisms in the intestinal cavity.It has been recognized as one of the body’ s most important barriers.These two can maintain the steady state of the intestinal environment through complex interactions.This article discussed the treatment strategy of IBD around the correlation between intestinal flora,intestinal immunity and inflammatory bowel disease.
作者
李悦
刘肃志
张志君
梅祖兵
杨巍
LI Yue;LIU Suzhi;ZHANG Zhijun;MEI Zubing;YANG Wei(Anorectal Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《辽宁中医杂志》
CAS
2020年第6期49-52,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81673768,81774112)。
关键词
炎症性肠病
肠道菌群
肠道黏膜免疫
治疗
inflammatory bowel disease
intestinal flora
intestinal mucosal immunity
treatment
