摘要
目的:研究不同程度抑郁症合并支气管哮喘患者血清白介素细胞-17(IL-17)、白介素细胞-6(IL-6)、肿瘤坏死因子-α(TNF-α)、5-羟色胺(5-HT)水平的差异。方法以2017年4月-2018年6月新疆医科大学第一附属医院呼吸科确诊支气管哮喘合并抑郁症的127例患者为研究对象,另选取同时期在体检中心体检的40例健康者为对照组。参照Zung氏抑郁自评量表(SDS)、Hamilton汉密尔顿抑郁量表(HAMD)标准将抑郁症患者轻度抑郁、中度抑郁、重度抑郁,采用ELISA法测定各组患者血清IL-17、TNF-α、IL-6表达水平,采高效液相色普法检测血清中5-HT水平。结果127例支气管哮喘合并抑郁患者中,轻度抑郁者68例(53.5%),中度抑郁27例(21.3%),重度抑郁32例(25.2%)。与对照组比较,支气管哮喘合并中、重度抑郁组患者血清中5-HT含量降低,差异有统计学意义(P<0.05)。与支气管哮喘合并轻度抑郁组患者比较,支气管哮喘合并中、重度抑郁组患者血清中5-HT含量降低,差异有统计学意义(P<0.05)。与对照组比较,支气管哮喘合并轻、中、重度抑组郁患者血清中IL-17含量升高,差异有统计学意义(P<0.05);哮喘合并不同程度的抑郁组之间患者血清中IL-17含量差异有统计学意义(P<0.05)。与对照组比较,支气管哮喘合并轻、中、重度抑郁组患者血清中IL-6和TNF-α含量均升高,差异有统计学差异(P<0.05)。IL-17与SDS标准分呈正相关(r=0.231,P<0.05),IL-6、TNF-α及5-HT与SDS得分无相关性(P>0.05)。结论患者血清中IL-17、IL-6、TNF-α、5-HT水平与支气管哮喘合并抑郁的发生存在密切关系,其中IL-17和5-HT与支气管哮喘合并抑郁的发展及病情严重程度密切相关。
Objective To study the differences of IL-17,IL-6,TNF-αand 5-hydroxytryptamine(5-HT)level in the serum of patients with different degrees of depression complicated with asthma.Methods From April 2017 to June 2018,127 patients with bronchial asthma and complicated with depression,who were diagnosed at the Department of Respiratory the First Affiliated Hospital of Xinjiang Medical University,were selected as the study object and divided into mild depression,moderate depression and severe depression patients with depression by the standard of Zung self rating Depression Scale(SDS)and Hamilton Depression Scale.Another 40 healthy people who had physical examination in the physical examination center during the same period were selected as the control group.The levels of IL-17,TNF-αand IL-6 in serum were measured by ELISA and 5-HT in serum was measured by HPLC.Results Among 127 patients with asthma and complicated with depression,68(53.5%)were mild depression,27(21.3%)were moderate depression and 32(25.2%)were severe depression.Compared with the control group,the 5-HT level in the serum of the patients with asthma complicated with moderate and severe depression was decreased significantly(P<0.05).Compared with the patients with asthma complicated with mild depression,the serum 5-HT level of the patients with asthma complicated with moderate and severe depression was decreased significantly(P<0.05).Compared with the control group,the level of IL-17 in the serum of the asthma patients complicated with mild,moderate and severe depression was increased significantly(P<0.05).Among the asthma patients complicated with different degrees of depression,the level of serum IL-17 was significantly different(P<0.05).Compared with the control group,the levels of IL-6 and TNF-αin the serum of the asthma patients complicated with mild,moderate and severe depression were all increased,the difference was statistically significant(P<0.05).IL-17 was positively correlated with SDS standard score(r=0.231,P<0.05),IL-6,TNF-αand 5-HT were n
作者
迪丽努尔·乌甫尔
才开·沙热力
海迪娅·艾尔肯
克丽别娜·吐尔逊
Dilinuer Wufuer;Caikai Shareli;Haidiya Aierken;Kelibiena Tuerxun(The First Ward of Respiratory and Critical Care Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Respiratory and Critical Care Unit,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《新疆医科大学学报》
CAS
2020年第7期905-908,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金(2017D01C329)。
